Genetic basis for congenital heart disease: revisited: a scientific statement from the American Heart Association
This review provides an updated summary of the state of our knowledge of the genetic
contributions to the pathogenesis of congenital heart disease. Since 2007, when the initial …
contributions to the pathogenesis of congenital heart disease. Since 2007, when the initial …
Chromatin modifiers and remodellers: regulators of cellular differentiation
T Chen, SYR Dent - Nature Reviews Genetics, 2014 - nature.com
Cellular differentiation is, by definition, epigenetic. Genome-wide profiling of pluripotent cells
and differentiated cells suggests global chromatin remodelling during differentiation, which …
and differentiated cells suggests global chromatin remodelling during differentiation, which …
Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands
Congenital heart disease (CHD) is the leading cause of mortality from birth defects. Here,
exome sequencing of a single cohort of 2,871 CHD probands, including 2,645 parent …
exome sequencing of a single cohort of 2,871 CHD probands, including 2,645 parent …
Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide
In the 1950s, the drug thalidomide, administered as a sedative to pregnant women, led to
the birth of thousands of children with multiple defects. Despite the teratogenicity of …
the birth of thousands of children with multiple defects. Despite the teratogenicity of …
De novo mutations in histone-modifying genes in congenital heart disease
Congenital heart disease (CHD) is the most frequent birth defect, affecting 0.8% of live
births. Many cases occur sporadically and impair reproductive fitness, suggesting a role for …
births. Many cases occur sporadically and impair reproductive fitness, suggesting a role for …
Epigenomic analysis of multilineage differentiation of human embryonic stem cells
Epigenetic mechanisms have been proposed to play crucial roles in mammalian
development, but their precise functions are only partially understood. To investigate …
development, but their precise functions are only partially understood. To investigate …
Meis1 regulates postnatal cardiomyocyte cell cycle arrest
AI Mahmoud, F Kocabas, SA Muralidhar, W Kimura… - Nature, 2013 - nature.com
The neonatal mammalian heart is capable of substantial regeneration following injury
through cardiomyocyte proliferation,. However, this regenerative capacity is lost by postnatal …
through cardiomyocyte proliferation,. However, this regenerative capacity is lost by postnatal …
[HTML][HTML] Mapping human epigenomes
CM Rivera, B Ren - Cell, 2013 - cell.com
As the second dimension to the genome, the epigenome contains key information specific to
every type of cells. Thousands of human epigenome maps have been produced in recent …
every type of cells. Thousands of human epigenome maps have been produced in recent …
Protein post-translational modifications and regulation of pluripotency in human stem cells
Post-translational modifications (PTMs) are known to be essential mechanisms used by
eukaryotic cells to diversify their protein functions and dynamically coordinate their signaling …
eukaryotic cells to diversify their protein functions and dynamically coordinate their signaling …
Pluripotent stem cells in regenerative medicine: challenges and recent progress
After years of incremental progress, several recent studies have succeeded in deriving
disease-relevant cell types from human pluripotent stem cell (hPSC) sources. The prospect …
disease-relevant cell types from human pluripotent stem cell (hPSC) sources. The prospect …