DeerLab: a comprehensive software package for analyzing dipolar electron paramagnetic resonance spectroscopy data
Dipolar electron paramagnetic resonance (EPR) spectroscopy (DEER and other techniques)
enables the structural characterization of macromolecular and biological systems by …
enables the structural characterization of macromolecular and biological systems by …
Benchmark test and guidelines for DEER/PELDOR experiments on nitroxide-labeled biomolecules
O Schiemann, CA Heubach, D Abdullin… - Journal of the …, 2021 - ACS Publications
Distance distribution information obtained by pulsed dipolar EPR spectroscopy provides an
important contribution to many studies in structural biology. Increasingly, such information is …
important contribution to many studies in structural biology. Increasingly, such information is …
Mechanism of allosteric modulation of P-glycoprotein by transport substrates and inhibitors
The ATP-binding cassette subfamily B member 1 (ABCB1) multidrug transporter P-
glycoprotein plays a central role in clearance of xenobiotics in humans and is implicated in …
glycoprotein plays a central role in clearance of xenobiotics in humans and is implicated in …
Impact of Cellular Crowding on Protein Structural Dynamics Investigated by EPR Spectroscopy
The study of how the intracellular medium influences protein structural dynamics and protein–
protein interactions is a captivating area of research for scientists aiming to comprehend …
protein interactions is a captivating area of research for scientists aiming to comprehend …
Integrating Electron Paramagnetic Resonance Spectroscopy and Computational Modeling to Measure Protein Structure and Dynamics
Electron paramagnetic resonance (EPR) has become a powerful probe of conformational
heterogeneity and dynamics of biomolecules. In this Review, we discuss different …
heterogeneity and dynamics of biomolecules. In this Review, we discuss different …
Integrated AlphaFold2 and DEER investigation of the conformational dynamics of a pH-dependent APC antiporter
D Del Alamo, L DeSousa, RM Nair… - Proceedings of the …, 2022 - National Acad Sciences
The Amino Acid–Polyamine-Organocation (APC) transporter GadC contributes to the
survival of pathogenic bacteria under extreme acid stress by exchanging extracellular …
survival of pathogenic bacteria under extreme acid stress by exchanging extracellular …
Tuning flavin environment to detect and control light-induced conformational switching in Drosophila cryptochrome
S Chandrasekaran, CM Schneps, R Dunleavy… - Communications …, 2021 - nature.com
Light-induction of an anionic semiquinone (SQ) flavin radical in Drosophila cryptochrome
(dCRY) alters the dCRY conformation to promote binding and degradation of the circadian …
(dCRY) alters the dCRY conformation to promote binding and degradation of the circadian …
Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter
Here we used cryo-electron microscopy (cryo-EM), double electron-electron resonance
spectroscopy (DEER), and molecular dynamics (MD) simulations, to capture and …
spectroscopy (DEER), and molecular dynamics (MD) simulations, to capture and …
[HTML][HTML] Protein functional dynamics from the rigorous global analysis of DEER data: Conditions, components, and conformations
EJ Hustedt, RA Stein, HS Mchaourab - Journal of General Physiology, 2021 - rupress.org
The potential of spin labeling to reveal the dynamic dimension of macromolecules has been
recognized since the dawn of the methodology in the 1960s. However, it was the …
recognized since the dawn of the methodology in the 1960s. However, it was the …
A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl–/H+ transport cycle
Among coupled exchangers, CLCs uniquely catalyze the exchange of oppositely charged
ions (Cl–for H+). Transport-cycle models to describe and explain this unusual mechanism …
ions (Cl–for H+). Transport-cycle models to describe and explain this unusual mechanism …