Our understanding of depression and its treatment has advanced with the advent of
ketamine as a rapid-acting antidepressant and the development and refinement of tools …

Early life stress–including experience of child maltreatment, neglect, separation from or loss
of a parent, and other forms of adversity–increases lifetime risk of mood, anxiety, and …

Dysregulated prefrontal control over amygdala is engaged in the pathogenesis of psychiatric
diseases including depression and anxiety disorders. Here we show that, in a rodent anxiety …

Anxiety often is studied as a stand-alone construct in laboratory models. But in the context of
coping with real-life anxiety, its negative impacts extend beyond aversive feelings and …

The fact that exposure to severe stress leads to the development of psychiatric disorders
serves as the basic rationale for animal models of stress disorders. Clinical and …

The processing of stress responses involves brain-wide communication among cortical and
subcortical regions; however, the underlying mechanisms remain elusive. Here, we show …

Brain-wide fluctuations in local field potential oscillations reflect emergent network-level
signals that mediate behavior. Cracking the code whereby these oscillations coordinate in …

Considerable individual differences exist in trait-like patterns of behavioral and physiological
responses to salient environmental challenges. This individual variation in stress coping …

Decreased pleasure-seeking (anhedonia) forms a core symptom of depression. Stressful
experiences precipitate depression and disrupt reward-seeking, but it remains unclear how …

Highlights•Individuals differ in the perception and adaptation to aversive and stressful
stimuli.•Stress-susceptibility is associated with functional changes in specific neural …