The circadian system in Alzheimer's disease: disturbances, mechanisms, and opportunities

AN Coogan, B Schutová, S Husung, K Furczyk… - Biological …, 2013 - Elsevier
Alzheimer's disease (AD) is a devastating neurodegenerative condition associated with
severe cognitive and behavioral impairments. Circadian rhythms are recurring cycles that …

[HTML][HTML] Disrupted sleep and circadian rhythms in schizophrenia and their interaction with dopamine signaling

A Ashton, A Jagannath - Frontiers in neuroscience, 2020 - frontiersin.org
Sleep and circadian rhythm disruption (SCRD) is a common feature of schizophrenia, and is
associated with symptom severity and patient quality of life. It is commonly manifested as …

[HTML][HTML] Psychotropic drug effects on steroid stress hormone release and possible mechanisms involved

Z Romanova, N Hlavacova, D Jezova - International Journal of Molecular …, 2022 - mdpi.com
There is no doubt that chronic stress accompanied by adrenocortical stress hormone
release affects the development and treatment outcome of several mental disorders. Less …

[HTML][HTML] Identification of pathways that regulate circadian rhythms using a larval zebrafish small molecule screen

EA Mosser, CN Chiu, TK Tamai, T Hirota, S Li, M Hui… - Scientific reports, 2019 - nature.com
The circadian clock ensures that behavioral and physiological processes occur at
appropriate times during the 24-hour day/night cycle, and is regulated at both the cellular …

Chronobiology of Parkinson's disease: Past, present and future

Z Asadpoordezaki, AN Coogan… - European Journal of …, 2023 - Wiley Online Library
Parkinson's disease is a neurodegenerative disorder predominately affecting midbrain
dopaminergic neurons that results in a broad range of motor and non‐motor symptoms …

The circadian clock gene Per1 modulates context fear memory formation within the retrosplenial cortex in a sex-specific manner

MW Urban, C Lo, KK Bodinayake, CA Brunswick… - Neurobiology of learning …, 2021 - Elsevier
Context memory formation is a complex process that requires transcription in many
subregions of the brain including the dorsal hippocampus and retrosplenial cortex. One …

Circadian clock components in the rat neocortex: daily dynamics, localization and regulation

MF Rath, K Rohde, J Fahrenkrug, M Møller - Brain Structure and Function, 2013 - Springer
The circadian master clock of the mammalian brain resides in the suprachiasmatic nucleus
(SCN) of the hypothalamus. At the molecular level, the clock of the SCN is driven by a …

Chronotherapeutics and psychiatry: setting the clock to relieve the symptoms

AN Coogan, J Thome - The World Journal of Biological Psychiatry, 2011 - Taylor & Francis
Circadian rhythms are near 24-h cycles in a number of physiological and behavioural
parameters and the underpinning circadian timing systems is one of the key homeostatic …

Daily methylphenidate and atomoxetine treatment impacts on clock gene protein expression in the mouse brain

AL Baird, AN Coogan, J Kaufling, M Barrot, J Thome - Brain research, 2013 - Elsevier
Circadian rhythms are repeating patterns of physiological and other parameters that recur
with periods of approximately 24h, and are generated by an endogenous circadian …

Circadian oscillators in the mouse brain: molecular clock components in the neocortex and cerebellar cortex

MF Rath, L Rovsing, M Møller - Cell and tissue research, 2014 - Springer
The circadian timekeeper of the mammalian brain resides in the suprachiasmatic nucleus of
the hypothalamus (SCN), and is characterized by rhythmic expression of a set of clock …