Functional roles of E3 ubiquitin ligases in prostate cancer

Y Zhao, J Li, J Chen, M Ye, X Jin - Journal of Molecular Medicine, 2022 - Springer
Prostate cancer (PCa) is a malignant epithelial tumor of the prostate gland with a high male
cancer incidence. Numerous studies indicate that abnormal function of ubiquitin …

Comparative pathobiology of canine and human prostate cancer: state of the art and future directions

EP Nascente, RL Amorim, CE Fonseca-Alves… - Cancers, 2022 - mdpi.com
Simple Summary Prostate cancer (PC) is one of the main types of cancer that affects the
male population worldwide. In recent decades, there has been a significant evolution in the …

Establishment of a dog primary prostate cancer organoid using the urine cancer stem cells

T Usui, M Sakurai, S Nishikawa, K Umata… - Cancer …, 2017 - Wiley Online Library
Dog spontaneously develop prostate cancer (PC) like humans. Because most dogs with PC
have a poor prognosis, they could be used as a translational model for advanced PC in …

An RNA-Seq-based framework for characterizing canine prostate cancer and prioritizing clinically relevant biomarker candidate genes

H Thiemeyer, L Taher, JT Schille, EM Packeiser… - International journal of …, 2021 - mdpi.com
Prostate cancer (PCa) in dogs is a highly malignant disease akin to its human counterpart. In
contrast to the situation in humans, multi-gene approaches facilitating risk stratification of …

Investigation of prognostic value of claudin-5, PSMA, and Ki67 expression in canine splenic hemangiosarcoma

JM Rozolen, TGW Teodoro, RA Sobral, FAR Sueiro… - Animals, 2021 - mdpi.com
Simple Summary Canine splenic hemangiosarcoma (HSA) is an aggressive cancer that
originates from endothelial cells. In clinical practice, it is commonly noted among canine …

Electrochemotherapy induces tumor regression and decreases the proliferative index in canine cutaneous squamous cell carcinoma

DS Dos Anjos, C Bueno, LF Magalhães… - Scientific reports, 2019 - nature.com
Canine cutaneous squamous cell carcinoma (cSCC) is the most common skin cancer in
dogs, and, due to its low metastatic rate, local treatments, such as electrochemotherapy …

Immunohistochemical panel to characterize canine prostate carcinomas according to aberrant p63 expression

CE Fonseca-Alves, PE Kobayashi… - PloS one, 2018 - journals.plos.org
An unusual variant of prostate adenocarcinoma (PC) expressing nuclear p63 in secretory
cells instead of the typical basal expression has been reported in men. Nevertheless, the …

Characterization of six canine prostate adenocarcinoma and three transitional cell carcinoma cell lines derived from primary tumor tissues as well as metastasis

EM Packeiser, M Hewicker-Trautwein, H Thiemeyer… - PLoS …, 2020 - journals.plos.org
Canine prostate adenocarcinoma (PAC) and transitional cell carcinoma (TCC) of prostate
and urinary bladder are highly invasive and metastatic tumors of closely neighbored organs …

Comprehensive genomic profiling of androgen-receptor-negative canine prostate cancer

R Laufer-Amorim, CE Fonseca-Alves… - International Journal of …, 2019 - mdpi.com
Canine carcinomas have been considered natural models for human diseases; however,
the genomic profile of canine prostate cancers (PCs) has not been explored. In this study, 14 …

Investigation of c-KIT and Ki67 expression in normal, preneoplastic and neoplastic canine prostate

CE Fonseca-Alves, PE Kobayashi, C Palmieri… - BMC veterinary …, 2017 - Springer
Background c-KIT expression has been related to bone metastasis in human prostate
cancer, but whether c-KIT expression can be similarly classified in canine prostatic tissue is …