[HTML][HTML] Juvenile idiopathic arthritis-associated genetic loci exhibit spatially constrained gene regulatory effects across multiple tissues and immune cell types
Juvenile idiopathic arthritis (JIA) is an autoimmune, inflammatory joint disease with complex
genetic etiology. Previous GWAS have found many genetic loci associated with JIA …
genetic etiology. Previous GWAS have found many genetic loci associated with JIA …
Discovering genetic mechanisms underlying the co-occurrence of Parkinson's disease and non-motor traits
Understanding the biological mechanisms that underlie the non-motor symptoms of
Parkinson's disease (PD) requires comprehensive frameworks that unravel the complex …
Parkinson's disease (PD) requires comprehensive frameworks that unravel the complex …
Analysis of associations between the TLR3 SNPs rs3775291 and rs3775290 and COVID-19 in a cohort of professionals of Belém-PA, Brazil
MJA Silva, MCS Vieira, AB Souza… - Frontiers in Cellular …, 2023 - frontiersin.org
The objective of this article was to verify associations between the SNPs rs3775291
(Cytosine [C]> Thymine [T]) and rs3775290 (C> T) of TLR3 in professionals from Health …
(Cytosine [C]> Thymine [T]) and rs3775290 (C> T) of TLR3 in professionals from Health …
A genome-wide association study of neutrophil count in individuals associated to an African continental ancestry group facilitates studies of malaria pathogenesis
Background'Benign ethnic neutropenia'(BEN) is a heritable condition characterized by lower
neutrophil counts, predominantly observed in individuals of African ancestry, and the genetic …
neutrophil counts, predominantly observed in individuals of African ancestry, and the genetic …
[HTML][HTML] A brief clinical genetics review: stepwise diagnostic processes of a monogenic disorder—hypertriglyceridemia
M Ueda - Translational Pediatrics, 2024 - pmc.ncbi.nlm.nih.gov
The completion of the Human Genome Project and tremendous advances in automated high-
throughput genetic analysis technologies have enabled explosive progress in the field of …
throughput genetic analysis technologies have enabled explosive progress in the field of …
Identification of 27 allele-specific regulatory variants in Parkinson's disease using a massively parallel reporter assay
Genome wide association studies (GWAS) have identified a number of genomic loci that are
associated with Parkinson's disease (PD) risk. However, the majority of these variants lie in …
associated with Parkinson's disease (PD) risk. However, the majority of these variants lie in …
De novo identification of complex traits associated with asthma
Introduction Asthma is a heterogeneous inflammatory disease often associated with other
complex phenotypes. Identifying asthma-associated diseases and uncovering the molecular …
complex phenotypes. Identifying asthma-associated diseases and uncovering the molecular …
A high-performance computational workflow to accelerate GATK SNP detection across a 25-genome dataset
Abstract Background Single-nucleotide polymorphisms (SNPs) are the most widely used
form of molecular genetic variation studies. As reference genomes and resequencing data …
form of molecular genetic variation studies. As reference genomes and resequencing data …
Unspecified asthma, childhood-onset, and adult-onset asthma have different causal genes: a Mendelian randomization analysis
Introduction Asthma is a heterogeneous condition that is characterized by reversible airway
obstruction. Childhood-onset asthma (COA) and adult-onset asthma (AOA) are two …
obstruction. Childhood-onset asthma (COA) and adult-onset asthma (AOA) are two …
Highly homologous miR-135a and miR-135b converting non-small cell lung cancer from suppression to progression via enhancer switching
K Zhou, W Li, L Chen, S Chen, M Liu… - Human Molecular …, 2024 - academic.oup.com
Abstract microRNAs (miRNAs) are short non-coding RNAs that have been increasingly
recognized for their significant roles in the progression of cancer. Distinct miRNAs exhibit …
recognized for their significant roles in the progression of cancer. Distinct miRNAs exhibit …