Oxidative stress and cardiac hypertrophy: a review
Cardiac hypertrophy (CH) is an adaptive response of the heart to pressure overload. It is a
common pathological feature in the natural course of some major cardiovascular diseases …
common pathological feature in the natural course of some major cardiovascular diseases …
Matrix metalloproteinase 2 as a potential mediator of vascular smooth muscle cell migration and chronic vascular remodeling in hypertension
VA Belo, DA Guimarães, MM Castro - Journal of vascular research, 2016 - karger.com
For vascular remodeling in hypertension, it is essential that vascular smooth muscle cells
(VSMCs) reshape in order to proliferate and migrate. The extracellular matrix (ECM) needs …
(VSMCs) reshape in order to proliferate and migrate. The extracellular matrix (ECM) needs …
[HTML][HTML] N-carboxymethyl chitosan/sodium alginate composite hydrogel loading plasmid DNA as a promising gene activated matrix for in-situ burn wound treatment
L Wang, L Sun, Z Gu, W Li, L Guo, S Ma, L Guo… - Bioactive Materials, 2022 - Elsevier
Improving the degree of vascularization through the regulation of wound microenvironment
is crucial for wound repair. Gene activated matrix (GAM) technology provides a new …
is crucial for wound repair. Gene activated matrix (GAM) technology provides a new …
MMP-2 and its implications on cardiac function and structure: interplay with inflammation in hypertension
Hypertension is one of the leading risk factors for the development of heart failure. Despite
being a multifactorial disease, in recent years, preclinical and clinical studies suggest strong …
being a multifactorial disease, in recent years, preclinical and clinical studies suggest strong …
Polymorphisms in genes related to oxidative stress and inflammation: Emerging links with the pathogenesis and severity of Cerebral Cavernous Malformation disease
A Perrelli, SF Retta - Free Radical Biology and Medicine, 2021 - Elsevier
Abstract Cerebral Cavernous Malformation (CCM) is a cerebrovascular disease of genetic
origin affecting 0.5% of the population and characterized by abnormally enlarged and leaky …
origin affecting 0.5% of the population and characterized by abnormally enlarged and leaky …
Matrix metalloproteinases are involved in cardiovascular diseases
A Azevedo, AF Prado, RC Antonio… - Basic & Clinical …, 2014 - Wiley Online Library
This MiniReview describes the essential biochemical and molecular aspects of matrix
metalloproteinases (MMP s) and briefly discusses how they engage in different diseases …
metalloproteinases (MMP s) and briefly discusses how they engage in different diseases …
Sources and effects of oxidative stress in hypertension
LC Pinheiro, GH Oliveira-Paula - Current hypertension reviews, 2020 - ingentaconnect.com
Background: Disruption of redox signaling is a common pathophysiological mechanism
observed in several diseases. In hypertension, oxidative stress, resulted either from …
observed in several diseases. In hypertension, oxidative stress, resulted either from …
[HTML][HTML] Quercetin decreases the activity of matrix metalloproteinase-2 and ameliorates vascular remodeling in renovascular hypertension
SC Pereira, JM Parente, VA Belo, AS Mendes… - Atherosclerosis, 2018 - Elsevier
Background and aims Increased activity of matrix metalloproteinase (MMP)-2 is observed in
aortas of different models of hypertension, and its activation is directly mediated by oxidative …
aortas of different models of hypertension, and its activation is directly mediated by oxidative …
[HTML][HTML] Nebivolol attenuates prooxidant and profibrotic mechanisms involving TGF-β and MMPs, and decreases vascular remodeling in renovascular hypertension
Nebivolol and metoprolol are β 1-adrenergic receptor blockers with different properties. We
hypothesized that nebivolol, but not metoprolol, could attenuate prooxidant and profibrotic …
hypothesized that nebivolol, but not metoprolol, could attenuate prooxidant and profibrotic …
Inhibition of matrix metalloproteinases (MMPs) as a potential strategy to ameliorate hypertension-induced cardiovascular alterations
MM Castro, JE Tanus-Santos - Current drug targets, 2013 - ingentaconnect.com
A group of proteases, the matrix metalloproteinases (MMPs) are well known for their
capacity to degrade extracellular matrix (ECM) proteins. Particularly MMP-2 and MMP-9 …
capacity to degrade extracellular matrix (ECM) proteins. Particularly MMP-2 and MMP-9 …