Exome sequencing as a tool for Mendelian disease gene discovery

MJ Bamshad, SB Ng, AW Bigham, HK Tabor… - Nature Reviews …, 2011 - nature.com
Exome sequencing—the targeted sequencing of the subset of the human genome that is
protein coding—is a powerful and cost-effective new tool for dissecting the genetic basis of …

Incidental findings on brain magnetic resonance imaging: systematic review and meta-analysis

Z Morris, WN Whiteley, WT Longstreth, F Weber… - Bmj, 2009 - bmj.com
Objective To quantify the prevalence of incidental findings on magnetic resonance imaging
(MRI) of the brain. Design Systematic review and meta-analysis of observational studies …

Broken promises of privacy: Responding to the surprising failure of anonymization

P Ohm - UCLA l. Rev., 2009 - HeinOnline
Imagine a database packed with sensitive information about many people. Perhaps this
database helps a hospital track its patients, a school its students, or a bank its customers …

Return of genomic results to research participants: the floor, the ceiling, and the choices in between

GP Jarvik, LM Amendola, JS Berg, K Brothers… - The American Journal of …, 2014 - cell.com
As more research studies incorporate next-generation sequencing (including whole-
genome or whole-exome sequencing), investigators and institutional review boards face …

[HTML][HTML] Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans

AJ Saykin, L Shen, X Yao, S Kim, K Nho… - Alzheimer's & …, 2015 - Elsevier
Introduction Genetic data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) have
been crucial in advancing the understanding of Alzheimer's disease (AD) pathophysiology …

Managing incidental findings on abdominal CT: white paper of the ACR incidental findings committee

LL Berland, SG Silverman, RM Gore… - Journal of the American …, 2010 - Elsevier
As multidetector CT has come to play a more central role in medical care and as CT image
quality has improved, there has been an increase in the frequency of detecting “incidental …

Charting a course for genomic medicine from base pairs to bedside

ED Green, MS Guyer… - Nature, 2011 - nature.com
There has been much progress in genomics in the ten years since a draft sequence of the
human genome was published. Opportunities for understanding health and disease are now …

[图书][B] The student's guide to cognitive neuroscience

J Ward - 2019 - taylorfrancis.com
Reflecting recent changes in the way cognition and the brain are studied, this thoroughly
updated fourth edition of this bestselling textbook provides a comprehensive and student …

What can exome sequencing do for you?

J Majewski, J Schwartzentruber, E Lalonde… - Journal of medical …, 2011 - jmg.bmj.com
Recent advances in next-generation sequencing technologies have brought a paradigm
shift in how medical researchers investigate both rare and common human disorders. The …

Managing incidental findings and research results in genomic research involving biobanks and archived data sets

SM Wolf, BN Crock, B Van Ness, F Lawrenz… - Genetics in …, 2012 - nature.com
Biobanks and archived data sets collecting samples and data have become crucial engines
of genetic and genomic research. Unresolved, however, is what responsibilities biobanks …