Alternative splicing is an important mechanism to regulate gene expression and to expand
the repertoire of gene products in order to accommodate an increase in complexity of …

The modENCODE (Model Organism Encyclopedia of DNA Elements) Consortium aimed to
map functional elements—including transcripts, chromatin marks, regulatory factor binding …

In Arabidopsis, the circadian clock central oscillator genes are important cellular
components to generate and maintain circadian rhythms. There is a negative feedback loop …

Alternative splicing (AS) is a genetically and epigenetically regulated pre-mRNA processing
to increase transcriptome and proteome diversity. Comprehensively decoding these …

Background Alternative splicing is primarily controlled by the activity of splicing factors and
by the elongation of the RNA polymerase II (RNAPII). Recent experiments have suggested a …

Alternative splicing (AS) is a tightly regulated mechanism that generates the complex human
proteome from a small number of genes. Cis-regulatory RNA motifs in exons and introns …

A compelling body of literature, based on next generation chromatin immunoprecipitation
and RNA sequencing of reward brain regions indicates that the regulation of the epigenetic …

Alternative splicing (AS) not only ensures the diversity of gene expression products, but also
closely correlated with genetic diseases. Therefore, knowledge about regulatory …

Mechanisms that generate transcript diversity are of fundamental importance in eukaryotes.
Although a large fraction of human protein-coding genes and lincRNAs produce more than …

Alternative splicing changes are closely linked to aging, though it remains unclear if they are
drivers or effects. As organisms age, splicing patterns change, varying gene isoform levels …