Increased human papillomavirus viral load is correlated to higher severity of cervical disease and poorer clinical outcome: A systematic review

SF Fobian, X Mei, J Crezee, BC Snoek… - Journal of Medical …, 2024 - Wiley Online Library
Cervical cancer is the fourth most common cancer in women worldwide and is caused by
persistent infection with high‐risk types of human papillomavirus (HPV). HPV viral load, the …

Cervical cancer heterogeneity: a constant battle against viruses and drugs

Q Sun, L Wang, C Zhang, Z Hong, Z Han - Biomarker Research, 2022 - Springer
Cervical cancer is the first identified human papillomavirus (HPV) associated cancer and the
most promising malignancy to be eliminated. However, the ever-changing virus subtypes …

Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer

L Zhou, Q Qiu, Q Zhou, J Li, M Yu, K Li, L Xu… - Nature …, 2022 - nature.com
Integration of human papillomavirus (HPV) DNA into the human genome is considered as a
key event in cervical carcinogenesis. Here, we perform comprehensive characterization of …

HPV integration generates a cellular super-enhancer which functions as ecDNA to regulate genome-wide transcription

R Tian, Z Huang, L Li, J Yuan, Q Zhang… - Nucleic Acids …, 2023 - academic.oup.com
Human papillomavirus (HPV) integration is a critical step in cervical cancer development;
however, the oncogenic mechanism at the genome-wide transcriptional level is still poorly …

Circulating HPV DNA as a marker for early detection of relapse in patients with cervical cancer

E Jeannot, A Latouche, C Bonneau… - Clinical Cancer …, 2021 - AACR
Purpose: Almost all cervical cancers are caused by human papillomavirus (HPV) and
patients with advanced stage are at high risk for relapse. Circulating HPV DNA (HPV ctDNA) …

Long-read sequencing reveals oncogenic mechanism of HPV-human fusion transcripts in cervical cancer

M Liu, Z Han, Y Zhi, Y Ruan, G Cao, G Wang, X Xu… - Translational …, 2023 - Elsevier
Integration of high-risk human papillomavirus (HPV) into the host genome is a crucial event
for the development of cervical cancer, however, the underlying mechanism of HPV …

A NGS-based blood test for the diagnosis of invasive HPV-associated carcinomas with extensive viral genomic characterization

X Sastre-Garau, M Diop, F Martin, G Dolivet… - Clinical Cancer …, 2021 - AACR
Purpose: Use of circulating tumor DNA (ctDNA) for diagnosis is limited regarding the low
number of target molecules in early-stage tumors. Human papillomavirus (HPV)–associated …

Single‐cell landscape highlights heterogenous microenvironment, novel immune reaction patterns, potential biomarkers and unique therapeutic strategies of cervical …

J Qiu, X Qu, Y Wang, C Guo, B Lv, Q Jiang… - Advanced …, 2023 - Wiley Online Library
Cervical adenocarcinomas (ADCs), including human papillomavirus (HPV)‐associated
(HPVA) and non‐HPVA (NHPVA), though exhibiting a more malignant phenotype and …

Implications of viral infections and oncogenesis in uterine cervical carcinoma etiology and pathogenesis

D Chu, T Liu, Y Yao - Frontiers in Microbiology, 2023 - frontiersin.org
Background Uterine Cervical Carcinoma (UCC) is the most prevalent gynecological
malignancy globally, with a rising incidence in recent years. Accumulating evidence …

Abortive Infection of Animal Cells: What Goes Wrong

A Embry, DB Gammon - Annual Review of Virology, 2024 - annualreviews.org
Even if a virus successfully binds to a cell, defects in any of the downstream steps of the viral
life cycle can preclude the production of infectious virus particles. Such abortive infections …