Abstract Amyotrophic Lateral Sclerosis (ALS) is a progressive, neurodegenerative disease
characterized by loss of upper motor neurons (UMN) and lower motor neurons (LMN) …

Objective The purpose of this study was to detect specific motor unit (MU) abnormalities in
people with amyotrophic lateral sclerosis (ALS) compared to controls using high-density …

Based on early evidence of in vitro neurotoxicity following exposure to serum derived from
patients with amyotrophic lateral sclerosis (ALS), several studies have attempted to explore …

Background Non-cell autonomous toxicity is one of the potential mechanisms implicated in
the etiopathogenesis of amyotrophic lateral sclerosis (ALS). However, the exact role of glial …

Background Cerebrospinal fluid from amyotrophic lateral sclerosis patients (ALS-CSF)
induces neurodegenerative changes in motor neurons and gliosis in sporadic ALS models …

Background Stroke leads to devastating impact on health as well as quality of life making it
one of the leading causes of disability. Restoring the functions of upper extremities after …

Skeletal muscle atrophy is the most prominent feature of amyotrophic lateral sclerosis (ALS),
an adult-onset neurodegenerative disease of motor neurons. However, the contribution of …

Disease modeling has become challenging in the context of amyotrophic lateral sclerosis
(ALS), as obtaining viable spinal motor neurons from postmortem patient tissue is an …

Amyotrophic lateral sclerosis (ALS) is a late-onset, neurodegenerative disease associated
with the loss of motor neurons in the spinal cord, brain stem and primary motor cortex. Deficit …

Results We found a 3.7 fold up-regulation in miR-206 expression in the gastrocnemius
muscle of ALS-CSF injected rats compared to normal control (Fig. 1 and Table 1, p< 0.05 NC …