Mitochondrial dysfunction has been implicated in the development of insulin resistance (IR);
however, a large variety of association and intervention studies as well as genetic …

Mitochondrial function is maintained by several strictly coordinated mechanisms, collectively
termed mitochondrial quality control mechanisms, including fusion and fission, degradation …

Accumulation of the protein tau characterises Alzheimer's disease and other tauopathies,
including familial forms of frontotemporal dementia (FTD) that carry pathogenic tau …

Diabetes profoundly alters fuel metabolism; both insulin deficiency and insulin resistance
are characterized by inefficient mitochondrial coupling and excessive production of reactive …

There is overwhelming evidence for an association between impaired mitochondrial function
and metabolic syndrome. Mitophagy, a process that selectively removes damaged …

Impaired estrogen receptor α (ERα) action promotes obesity and metabolic dysfunction in
humans and mice; however, the mechanisms underlying these phenotypes remain …

Insulin resistance is a major risk factor for numerous diseases, including type 2 diabetes and
cardiovascular disease. These disorders have dramatically increased in incidence with …

Maternal obesity impairs offspring health, but the responsible mechanisms are not fully
established. To address this question, we fed female mice a high-fat/high-sugar diet from …

Introduction: Obesity and type 2 diabetes are growing health problems worldwide. The three
principal diabetogenic factors are adiposity, insulin resistance in skeletal muscle, and …

Dysregulation of lipid homeostasis is a precipitating event in the pathogenesis and
progression of hepatosteatosis and metabolic syndrome. These conditions are highly …