Roles of transposable elements in the regulation of mammalian transcription
Transposable elements (TEs) comprise about half of the mammalian genome. TEs often
contain sequences capable of recruiting the host transcription machinery, which they use to …
contain sequences capable of recruiting the host transcription machinery, which they use to …
Insights into epigenetic patterns in mammalian early embryos
R Xu, C Li, X Liu, S Gao - Protein & cell, 2021 - academic.oup.com
Mammalian fertilization begins with the fusion of two specialized gametes, followed by major
epigenetic remodeling leading to the formation of a totipotent embryo. During the …
epigenetic remodeling leading to the formation of a totipotent embryo. During the …
NR5A2 connects zygotic genome activation to the first lineage segregation in totipotent embryos
Zygotic genome activation (ZGA) marks the beginning of the embryonic program for a
totipotent embryo, which gives rise to the inner cell mass (ICM) where pluripotent epiblast …
totipotent embryo, which gives rise to the inner cell mass (ICM) where pluripotent epiblast …
Locus-specific expression of transposable elements in single cells with CELLO-seq
Transposable elements (TEs) regulate diverse biological processes, from early development
to cancer. Expression of young TEs is difficult to measure with next-generation, single-cell …
to cancer. Expression of young TEs is difficult to measure with next-generation, single-cell …
[HTML][HTML] A single-cell transcriptomics CRISPR-activation screen identifies epigenetic regulators of the zygotic genome activation program
C Alda-Catalinas, D Bredikhin, I Hernando-Herraez… - Cell systems, 2020 - cell.com
Zygotic genome activation (ZGA) is an essential transcriptional event in embryonic
development that coincides with extensive epigenetic reprogramming. Complex …
development that coincides with extensive epigenetic reprogramming. Complex …
TRF2-mediated telomere protection is dispensable in pluripotent stem cells
M Markiewicz-Potoczny, A Lobanova, AM Loeb… - Nature, 2021 - nature.com
In mammals, telomere protection is mediated by the essential protein TRF2, which binds
chromosome ends and ensures genome integrity,. TRF2 depletion results in end-to-end …
chromosome ends and ensures genome integrity,. TRF2 depletion results in end-to-end …
ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation
Zar1 was one of the earliest mammalian maternal-effect genes to be identified. Embryos
derived from Zar1-null female mice are blocked before zygotic genome activation; however …
derived from Zar1-null female mice are blocked before zygotic genome activation; however …
Epigenetic reprogramming in early animal development
Dramatic nuclear reorganization occurs during early development to convert terminally
differentiated gametes to a totipotent zygote, which then gives rise to an embryo. Aberrant …
differentiated gametes to a totipotent zygote, which then gives rise to an embryo. Aberrant …
Rise and SINE: Roles of transcription factors and retrotransposons in zygotic genome activation
P Kravchenko, K Tachibana - Nature Reviews Molecular Cell Biology, 2024 - nature.com
In sexually reproducing organisms, life begins with the fusion of transcriptionally silent
gametes, the oocyte and sperm. Although initiation of transcription in the embryo, known as …
gametes, the oocyte and sperm. Although initiation of transcription in the embryo, known as …
Retrotransposon renaissance in early embryos
Despite being the predominant genetic elements in mammalian genomes, retrotransposons
were often dismissed as genomic parasites with ambiguous biological significance …
were often dismissed as genomic parasites with ambiguous biological significance …