Isothermal amplification of nucleic acids is a simple process that rapidly and efficiently
accumulates nucleic acid sequences at constant temperature. Since the early 1990s …

Intracellular delivery is a critical step in biological discoveries and has been widely utilized
in biomedical research. A variety of molecular tools have been developed for cell-based …

Tumor derived exosomes (TEXs) have emerged as promising biomarkers for cancer liquid
biopsy. Conventional methods (such as ELISA and qRT-PCR) and emerging biosensing …

Liver metastases develop in more than half of the patients with colorectal cancer (CRC) and
are associated with a poor prognosis. The factors influencing liver metastasis of CRC are …

Extracellular vesicles (EVs) can facilitate essential communication among cells in a range of
pathophysiological conditions including cancer metastasis and progression, immune …

Local acidification of stroma is proposed to favour pre-metastatic niche formation but the
mechanism of initiation is unclear. We investigated whether Human Melanoma-derived …

Recently, sensitive and selective detection of exosomal microRNAs (miRNAs) has been
garnering significant attention, because it is related to many complex diseases, including …

Extracellular vesicles (EVs) are cell-derived membranous particles that play a crucial role in
molecular trafficking, intercellular transport and the egress of unwanted proteins. They have …

Sensitive and selective detection of microRNAs (miRNAs) in cancer cells derived exosomes
have attracted rapidly growing interest owing to their potential in diagnostic and prognostic …

The clustered regularly interspaced short palindromic repeats (CRISPR)/associated
nuclease (Cas) system is an efficient gene editing tool. In this study, it is found that both …