Monocytes (Mo) and macrophages (Mϕ) are key components of the innate immune system
and are involved in regulation of the initiation, development, and resolution of many …

Type 1 diabetes (T1D) results from destruction of pancreatic beta cells by T cells of the
immune system. Despite improvements in insulin analogs and continuous blood glucose …

Macrophages play a key role in defending against foreign pathogens, healing wounds, and
regulating tissue homeostasis. Driving this versatility is their phenotypic plasticity, which …

Macrophages and neutrophils are key components involved in the regulation of numerous
chronic inflammatory diseases, infectious disorders, and especially certain autoimmune …

Rationale: Macrophages play critical roles in the pathogenesis of type 1 diabetes mellitus
(T1DM). Circular RNAs (circRNAs) are a novel class of endogenous RNAs with covalently …

Treatment of C57BL/6 or NOD mice with a monoclonal antibody to the CSF-1 receptor
resulted in depletion of the resident macrophages of pancreatic islets of Langerhans that …

Macrophages are multifunctional immune cells that may either drive or modulate disease
pathogenesis depending on their activation phenotype. Autoimmune type 1 diabetes (T1D) …

There are three prerequisites for development of the autoimmune disease type 1 diabetes
(T1D). First, β cell-reactive T cells need to be activated; second, the response needs to be …

We have shown that nanoparticles (NPs) can be used as ligand-multimerization platforms to
activate specific cellular receptors in vivo. Nanoparticles coated with autoimmune disease …

Diabetes mellitus results from immune cell invasion into pancreatic islets of Langerhans,
eventually leading to selective destruction of the insulin-producing β-cells. How this process …