Genetic and biological drivers of prostate cancer disparities in Black men

J Gong, DM Kim, MR Freeman, H Kim, L Ellis… - Nature Reviews …, 2024 - nature.com
Black men with prostate cancer have historically had worse outcomes than white men with
prostate cancer. The causes of this disparity in outcomes are multi-factorial, but a potential …

Genomic, epigenomic, and transcriptomic signatures of prostate cancer between African American and European American patients

C Stevens, A Hightower, SG Buxbaum… - Frontiers in …, 2023 - frontiersin.org
Prostate cancer is the second most common cancer in men in the United States, and racial
disparities are greatly observed in the disease. Specifically, African American (AA) patients …

Race-based screening under the public health ethics microscope—the case of prostate cancer

C Arenas-Gallo, M Michie, N Jones… - … England Journal of …, 2024 - Mass Medical Soc
Race-Based Screening under the Public Health Ethics Microscope — The Case of Prostate
Cancer Page 1 Medicine and Society The new england journal of medicine n engl j med 391;5 …

Unique Spectrum of Activating BRAF Alterations in Prostate Cancer

A Chehrazi-Raffle, H Tukachinsky, E Toye… - Clinical Cancer …, 2023 - AACR
Purpose: Alterations in BRAF have been reported in 3% to 5% of prostate cancer, although
further characterization is lacking. Here, we describe the nature of BRAF alterations in …

[HTML][HTML] CRISPR screening reveals gleason score and castration resistance related oncodriver ring finger protein 19 A (RNF19A) in prostate cancer

N Zhang, D Huang, X Ruan, ATL Ng, JHL Tsu… - Drug Resistance …, 2023 - Elsevier
Prostate cancer (PCa) is one of the most lethal causes of cancer-related death in male. It is
characterized by chromosomal instability and disturbed signaling transduction. E3 ubiquitin …

Preclinical models of prostate cancer—Modelling androgen dependency and castration resistance in vitro, ex vivo and in vivo

L Germain, C Lafront, V Paquette, B Neveu… - Nature Reviews …, 2023 - nature.com
Prostate cancer is well known to be dependent on the androgen receptor (AR) for growth
and survival. Thus, AR is the main pharmacological target to treat this disease. However …

[HTML][HTML] Current landscape of exosomal non-coding RNAs in prostate cancer: Modulators and biomarkers

Y Li, X Tang, B Wang, M Chen, Z Ji, K Chang - Non-coding RNA Research, 2024 - Elsevier
Prostate cancer (PCa) has the highest frequency of diagnosis among solid tumors and ranks
second as the primary cause of cancer-related deaths. Non-coding RNAs (ncRNAs), such as …

Disparities With Systemic Therapies for Black Men Having Advanced Prostate Cancer: Where Do We Stand?

J Gong, DM Kim, AM De Hoedt, N Bhowmick… - Journal of Clinical …, 2024 - ascopubs.org
PURPOSE Prostate cancer represents the most common cancer diagnosis in Black men and
is the second leading cause of cancer death in this population. Multilevel disparities have …

Actionable genomic alterations in prostate cancer among Black and White United States veterans

LF Valle, NG Nickols, R Hausler, PR Alba… - The …, 2023 - academic.oup.com
Black Veterans have higher a incidence of localized and metastatic prostate cancer
compared to White Veterans yet are underrepresented in reports of frequencies of somatic …

Prostate cancer genetic alterations in Hispanic men

C Arenas‐Gallo, S Rhodes, JA Garcia… - The …, 2023 - Wiley Online Library
Background Differences in DNA alterations in prostate cancer among White, Black, and
Asian men have been widely described. This is the first description of the frequency of DNA …