Background Long intergenic non-coding RNAs (lncRNAs) are a class of non-coding RNAs
that are involved in gene expression regulation. Taurine up-regulated gene 1 (TUG1) is a …

Abstract The switch-independent 3 (SIN3)/histone deacetylase (HDAC) complexes play
essential roles in regulating chromatin accessibility and gene expression. There are two …

Genomics and other large-scale analyses have drawn increasing attention to the potential
impacts of transposable elements (TEs) on their host genomes. However, it remains …

Globally, cardiovascular diseases (CVDs) are among the leading causes of death. In light of
the high prevalence and mortality of CVDs, it is imperative to understand the molecules …

Histone deacetylase (HDAC) proteins participate in diverse and tissue-specific
developmental processes by forming various corepressor complexes with different …

Chromatin remodeling is essential to allow full development of alternative gene expression
programs in response to environmental changes. In fission yeast, oxidative stress triggers …

Summary Target of Rapamycin Complex 1 (TORC1) signaling promotes growth and aging.
Inhibition of TORC1 leads to reduced protein translation, which promotes longevity. TORC1 …

Many proteins remain poorly characterized even in well-studied organisms, presenting a
bottleneck for research. We applied phenomics and machine-learning approaches with …

Meiotic drivers bias gametogenesis to ensure their transmission into more than half the
offspring of a heterozygote. In Schizosaccharomyces pombe, wtf meiotic drivers destroy the …

The Schizosaccharomyces pombe Clr6S complex, a class I histone deacetylase complex,
functions as a zinc-dependent enzyme to remove acetyl groups from lysine residues in …