Objective This systematic review and meta‐analysis aimed to examine: the pooled
prevalence of symptomatic behaviours and mental health deterioration amongst individuals …

Executive summary Every infant, child, and adolescent will experience pain at times
throughout their life. Childhood pain ranges from acute to chronic, and includes procedural …

Background Pediatric patients with diffuse intrinsic pontine glioma (DIPG) have a poor
prognosis, with a median survival of less than 1 year. Oncolytic viral therapy has been …

Context In the spring of 2020, US schools closed to in-person teaching and sports were
cancelled to control the transmission of coronavirus disease 2019 (COVID-19). It is critical to …

Background For many individuals, the COVID-19 outbreak has increased their psychological
distress, changed their behaviors, and impacted their health. With more time spent indoors …

Background No approved therapies exist for inoperable plexiform neurofibromas in patients
with neurofibromatosis type 1. Methods We conducted an open-label, phase 2 trial of …

Abstract Background The International Scientific Society on Scoliosis Orthopaedic and
Rehabilitation Treatment (SOSORT) produced its first guidelines in 2005 and renewed them …

Background Dravet syndrome is a rare, treatment-resistant developmental epileptic
encephalopathy characterised by multiple types of frequent, disabling seizures …

Designed by a group of ME/CFS researchers and health professionals, the European
Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE) has …

Significant improvements have been achieved in cardiac arrest resuscitation and postarrest
resuscitation care, but mortality remains high. Most of the poor outcomes and deaths of …