Machine learning techniques for personalised medicine approaches in immune-mediated chronic inflammatory diseases: applications and challenges

J Peng, EC Jury, P Dönnes, C Ciurtin - Frontiers in pharmacology, 2021 - frontiersin.org
In the past decade, the emergence of machine learning (ML) applications has led to
significant advances towards implementation of personalised medicine approaches for …

The promise of precision medicine in rheumatology

JM Guthridge, CA Wagner, JA James - Nature medicine, 2022 - nature.com
Systemic autoimmune rheumatic diseases (SARDs) exhibit extensive heterogeneity in
clinical presentation, disease course, and treatment response. Therefore, precision …

Signatures of GVHD and relapse after posttransplant cyclophosphamide revealed by immune profiling and machine learning

SR McCurdy, V Radojcic, HL Tsai… - Blood, The Journal …, 2022 - ashpublications.org
The key immunologic signatures associated with clinical outcomes after posttransplant
cyclophosphamide (PTCy)-based HLA-haploidentical (haplo) and HLA-matched bone …

An introduction to machine learning and analysis of its use in rheumatic diseases

KM Kingsmore, CE Puglisi, AC Grammer… - Nature Reviews …, 2021 - nature.com
Abstract Machine learning (ML) is a computerized analytical technique that is being
increasingly employed in biomedicine. ML often provides an advantage over explicitly …

Precision medicine in systemic lupus erythematosus

S Fasano, A Milone, GF Nicoletti, DA Isenberg… - Nature Reviews …, 2023 - nature.com
Systemic lupus erythematosus (SLE) is an autoimmune disease that has diverse clinical
manifestations, ranging from restricted cutaneous involvement to life-threatening systemic …

The impact of artificial intelligence in the odyssey of rare diseases

A Visibelli, B Roncaglia, O Spiga, A Santucci - Biomedicines, 2023 - mdpi.com
Emerging machine learning (ML) technologies have the potential to significantly improve the
research and treatment of rare diseases, which constitute a vast set of diseases that affect a …

Investigating sex differences in T regulatory cells from cisgender and transgender healthy individuals and patients with autoimmune inflammatory disease: a cross …

GA Robinson, J Peng, H Peckham, G Butler… - The Lancet …, 2022 - thelancet.com
Background Sexual dimorphisms, which vary depending on age group and pubertal status,
have been described across both the innate and adaptive immune system. We explored the …

Lupus nephritis risk factors and biomarkers: An update

Y Renaudineau, W Brooks, J Belliere - International Journal of Molecular …, 2023 - mdpi.com
Lupus nephritis (LN) represents the most severe organ manifestation of systemic lupus
erythematosus (SLE) in terms of morbidity and mortality. To reduce these risks, tremendous …

[HTML][HTML] COVID-19 and systemic lupus erythematosus: a case series

Y Gartshteyn, AD Askanase, NM Schmidt… - The Lancet …, 2020 - ncbi.nlm.nih.gov
The COVID-19 pandemic has spread across New York City, NY, USA, affecting more than
150 000 of its 8· 5 million inhabitants as of April 26, 2020. 1 Severe illness resulting in …

A study of the recent trends of immunology: Key challenges, domains, applications, datasets, and future directions

S Pandya, A Thakur, S Saxena, N Jassal, C Patel… - Sensors, 2021 - mdpi.com
The human immune system is very complex. Understanding it traditionally required
specialized knowledge and expertise along with years of study. However, in recent times …