Mechanisms and disease consequences of nonalcoholic fatty liver disease

R Loomba, SL Friedman, GI Shulman - Cell, 2021 - cell.com
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …

Hepatic encephalopathy: Novel insights into classification, pathophysiology and therapy

CF Rose, P Amodio, JS Bajaj, RK Dhiman… - Journal of …, 2020 - Elsevier
Hepatic encephalopathy (HE) is a frequent and serious complication of both chronic liver
disease and acute liver failure. HE manifests as a wide spectrum of neuropsychiatric …

EASL Clinical Practice Guidelines on the management of hepatic encephalopathy

S Montagnese, PE Rautou, M Romero-Gómez… - Journal of …, 2022 - Elsevier
Summary The EASL Clinical Practice Guidelines (CPGs) on the management of hepatic
encephalopathy (HE) present evidence-based answers to a set of relevant questions (where …

Physiological β-amyloid clearance by the liver and its therapeutic potential for Alzheimer's disease

Y Cheng, CY He, DY Tian, SH Chen, JR Ren… - Acta …, 2023 - Springer
Cerebral amyloid-β (Aβ) accumulation due to impaired Aβ clearance is a pivotal event in the
pathogenesis of Alzheimer's disease (AD). Considerable brain-derived Aβ is cleared via …

Obesity-induced inflammation: connecting the periphery to the brain

O Le Thuc, C García-Cáceres - Nature Metabolism, 2024 - nature.com
Obesity is often associated with a chronic, low-grade inflammatory state affecting the entire
body. This sustained inflammatory state disrupts the coordinated communication between …

Obesity and aging: Molecular mechanisms and therapeutic approaches

AL Santos, S Sinha - Ageing Research Reviews, 2021 - Elsevier
The epidemic of obesity is a major challenge for health policymakers due to its far-reaching
effects on population health and potentially overwhelming financial burden on healthcare …

Association of altered liver enzymes with Alzheimer disease diagnosis, cognition, neuroimaging measures, and cerebrospinal fluid biomarkers

K Nho, A Kueider-Paisley, S Ahmad… - JAMA network …, 2019 - jamanetwork.com
Importance Increasing evidence suggests an important role of liver function in the
pathophysiology of Alzheimer disease (AD). The liver is a major metabolic hub; therefore …

Metabolic inflammation—a role for hepatic inflammatory pathways as drivers of comorbidities in nonalcoholic fatty liver disease?

N Gehrke, JM Schattenberg - Gastroenterology, 2020 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is a global and growing health concern. Emerging
evidence points toward metabolic inflammation as a key process in the fatty liver that …

Cognitive dysfunction in non-alcoholic fatty liver disease—current knowledge, mechanisms and perspectives

K Kjærgaard, ACD Mikkelsen, CW Wernberg… - Journal of Clinical …, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) has emerged as the hepatic component of the
metabolic syndrome and now seemingly affects one-fourth of the world population. Features …

Novel insights into non-alcoholic fatty liver disease and dementia: insulin resistance, hyperammonemia, gut dysbiosis, vascular impairment, and inflammation

SY Cheon, J Song - Cell & Bioscience, 2022 - Springer
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease characterized by multiple
pathologies. The progression of dementia with NAFLD may be affected by various risk …