Piperidines are among the most important synthetic fragments for designing drugs and play
a significant role in the pharmaceutical industry. Their derivatives are present in more than …

Although carbon is the central element of organic chemistry, oxygen is the central element of
stereoelectronic control in organic chemistry. Generally, a molecule with a C–O bond has …

Azetidines are prominent structural scaffolds in bioactive molecules, medicinal chemistry,
and ligand design for transition metals. However, state-of-the-art methods cannot be applied …

Catalysis has a central role in organic synthetic methodology, especially in stereoselective
reactions. In many reactions, enantioselectivity is made possible through the use of chiral …

One of the simplest organic functional groups, the alkyne, offers a broad canvas for the
design of cascade transformations in which up to three new bonds can be added to each of …

A general anti-Baldwin radical 4-exo-dig cyclization from nitrogen-substituted alkynes is
reported. Upon reaction with a heteroleptic copper complex in the presence of an amine and …

The importance of intramolecular constraints in cyclic transition-state geometries is
especially pronounced in n-endo-tet cyclizations, where the usual backside approach of a …

This review outlines the role of hyperconjugative interactions in the structure and reactivity of
organic molecules. After defining the common hyperconjugative patterns, we discuss the …

Despite their intriguing photophysical and photochemical activities, naturally occurring
photoenzymes have not yet been repurposed for new-to-nature activities. Here we …

Chiral heterocyclic compounds are needed for important medicinal applications. We report
an in silico strategy for the biocatalytic synthesis of chiral N-and O-heterocycles via Baldwin …