Single cell sequencing (SCS) can be harnessed to acquire the genomes, transcriptomes
and epigenomes from individual cells. Next generation sequencing (NGS) technology is the …

I review recent technological advancements in coupling single-cell transcriptomics with
cellular phenotypes including morphology, calcium signaling, and electrophysiology. Single …

Concerns that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2), the etiological agent of coronavirus disease 2019 (COVID-19), may cause new-onset …

Memory B cells (MBCs) can persist for a lifetime, but the mechanisms that allow their long-
term survival remain poorly understood. Here, we isolated and analyzed human splenic …

Human pancreatic plasticity is implied from multiple single-cell RNA sequencing (scRNA-
seq) studies. However, these have been invariably based on static datasets from which fate …

The atrioventricular (AV) conduction axis provides electrical continuity between the atrial
and ventricular chambers. The" nodal" cardiomyocytes populating this region (AV canal in …

While adult pancreatic stem cells are thought not to exist, it is now appreciated that the
acinar compartment harbors progenitors, including tissue-repairing facultative progenitors …

Understanding the origin of pancreatic β cells has profound implications for regenerative
therapies in diabetes. For over a century, it was widely held that adult pancreatic duct cells …

Tumor heterogeneity is a major challenge for oncology drug discovery and development.
Understanding of the spatial tumor landscape is key to identifying new targets and impactful …

Summary Type 1 (T1D) or type 2 diabetes (T2D) are caused by a deficit of functional insulin-
producing β cells. Thus, the identification of β cell trophic agents could allow the …