Aging induces molecular, cellular and functional changes in the adult brain that drive
cognitive decline and increase vulnerability to dementia-related neurodegenerative …

Synapses are well known as the main structures responsible for transmitting information
through the release and recognition of neurotransmitters by pre-and post-synaptic neurons …

Soluble β-amyloid (Aβ) oligomers impair synaptic plasticity and cause synaptic loss
associated with Alzheimer's disease (AD). We report that murine PirB (paired …

Selective neurodegeneration is a critical causal factor in Alzheimer's disease (AD); however,
the mechanisms that lead some neurons to perish, whereas others remain resilient, are …

Background The necessity of including both males and females in molecular neuroscience
research is now well understood. However, there is relatively limited basic biological data on …

Proper development of the central nervous system (CNS) requires the establishment of
appropriate connections between neurons. Recent work suggests that this process is …

It is estimated that Alzheimer's disease (AD) affects tens of millions of people, comprising not
only suffering patients, but also their relatives and caregivers. AD is one of age-related …

Epidemiological studies and mouse models suggest that maternal immune activation,
induced clinically through prenatal exposure to one of several infectious diseases, is a risk …

Although the etiology of schizophrenia (SZ) remains unknown, it is increasingly clear that
immune dysregulation plays a central role. Genome-wide association studies reproducibly …

Background Type 2 diabetes mellitus (T2D) is associated with an increased risk of cognitive
dysfunction. Angiopoietin-like protein 8 (ANGPTL8) is an important regulator in T2D, but the …