Melanoma metabolism can be reprogrammed by activating BRAF mutations. These
mutations are present in up to 50% of cutaneous melanomas, with the most common being …

Background and objectives Non-alcoholic fatty liver disease (NAFLD) develops due to
impaired hepatic lipid fluxes and is a risk factor for chronic liver disease and atherosclerosis …

The metabolic syndrome (MetS) is a cluster of cardiovascular risk factors characterised by
central obesity, atherogenic dyslipidaemia, and changes in the circulating lipidome; the …

Squalene is a key minor component of virgin olive oil, the main source of fat in the
Mediterranean diet, and had shown to improve the liver metabolism in rabbits and mice. The …

Background Adipose tissue is a source of multiple factors that modulate systemic insulin
sensitivity and cardiovascular risk. Taurine is obtained from the diet but it is less known that it …

Both cancer and cardio-metabolic disease disparities exist among specific populations in
the US. For example, African Americans experience the highest rates of breast and prostate …

Background Aberrant epigenetic modifications such as DNA methylation may contribute to
the pathogenesis of DR. We aimed at elucidating the role of novel DNA methylation …

Recently, the development of nonalcoholic steatohepatitis (NASH) in common strains of pigs
has been achieved using a diet high in saturated fat, fructose, cholesterol, and cholate and …

Overexpression of the kynurenine pathway is implicated in Alzheimer's disease and
Huntington's disease, due to the accumulation of the neurotoxic metabolites 3 …

When using Markov chain Monte Carlo (MCMC) algorithms to perform inference for
Bayesian clustering models, such as mixture models, the output is typically a sample of …