Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential

I Batinić-Haberle, JS Rebouças… - Antioxidants & redox …, 2010 - liebertpub.com
Oxidative stress has become widely viewed as an underlying condition in a number of
diseases, such as ischemia–reperfusion disorders, central nervous system disorders …

Mechanisms of inflammatory responses to radiation and normal tissues toxicity: clinical implications

M Najafi, E Motevaseli, A Shirazi, G Geraily… - … journal of radiation …, 2018 - Taylor & Francis
Purpose: Cancer treatment is one of the most challenging diseases in the present era.
Among a few modalities for cancer therapy, radiotherapy plays a pivotal role in more than …

[图书][B] Handbook Of Porphyrin Science: With Applications To Chemistry, Physics, Materials Science, Engineering, Biology And Medicine (Volumes 6-10)

KM Kadish, R Guilard, KM Smith - 2010 - books.google.com
This is the second set of Handbook of Porphyrin Science. Porphyrins, phthalocyanines and
their numerous analogues and derivatives are materials of tremendous importance in …

SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways

I Batinic-Haberle, A Tovmasyan… - Antioxidants & redox …, 2014 - liebertpub.com
Significance: Superoxide dismutase (SOD) enzymes are indispensable and ubiquitous
antioxidant defenses maintaining the steady-state levels of O2·−; no wonder, thus, that their …

Mn porphyrin-based redox-active drugs: differential effects as cancer therapeutics and protectors of normal tissue against oxidative injury

I Batinic-Haberle, A Tovmasyan… - Antioxidants & Redox …, 2018 - liebertpub.com
Significance: After approximatelty three decades of research, two Mn (III) porphyrins (MnPs),
MnTE-2-PyP5+ (BMX-010, AEOL10113) and MnTnBuOE-2-PyP5+ (BMX-001), have …

Tissue fibrosis induced by radiotherapy: current understanding of the molecular mechanisms, diagnosis and therapeutic advances

Z Yu, C Xu, B Song, S Zhang, C Chen, C Li… - Journal of Translational …, 2023 - Springer
Cancer remains the leading cause of death around the world. In cancer treatment, over 50%
of cancer patients receive radiotherapy alone or in multimodal combinations with other …

Redox-modulated phenomena and radiation therapy: the central role of superoxide dismutases

AK Holley, L Miao, DK St. Clair… - Antioxidants & redox …, 2014 - liebertpub.com
Significance: Ionizing radiation is a vital component in the oncologist's arsenal for the
treatment of cancer. Approximately 50% of all cancer patients will receive some form of …

Metformin as a radiation modifier; implications to normal tissue protection and tumor sensitization

K Mortezaee, D Shabeeb, AE Musa… - Current clinical …, 2019 - ingentaconnect.com
Background: Nowadays, ionizing radiation is used for several applications in medicine,
industry, agriculture, and nuclear power generation. Besides the beneficial roles of ionizing …

Reactive oxygen species drive epigenetic changes in radiation‐induced fibrosis

S Shrishrimal, EA Kosmacek… - … medicine and cellular …, 2019 - Wiley Online Library
Radiation‐induced fibrosis (RIF) develops months to years after initial radiation exposure.
RIF occurs when normal fibroblasts differentiate into myofibroblasts and lay down aberrant …

Diverse functions of cationic Mn (III) N-substituted pyridylporphyrins, recognized as SOD mimics

I Batinic-Haberle, Z Rajic, A Tovmasyan… - Free Radical Biology …, 2011 - Elsevier
Oxidative stress, a redox imbalance between the endogenous reactive species and
antioxidant systems, is common to numerous pathological conditions such as cancer, central …