Plasticity of epithelial cells during skin wound healing
Epithelial tissues line the outer surfaces of the mammalian body and protect from external
harm. In skin, the epithelium is maintained by distinct stem cell populations residing in the …
harm. In skin, the epithelium is maintained by distinct stem cell populations residing in the …
Engineered plant-derived nanovesicles facilitate tumor therapy: natural bioactivity plus drug controlled release platform
X Chen, S Ji, Y Yan, S Lin, L He, X Huang… - International Journal …, 2023 - Taylor & Francis
Tumors are the second-most common disease in the world, killing people at an alarming
rate. As issues with drug resistance, lack of targeting, and severe side effects are revealed …
rate. As issues with drug resistance, lack of targeting, and severe side effects are revealed …
[HTML][HTML] Dedifferentiation maintains melanocyte stem cells in a dynamic niche
For unknow reasons, the melanocyte stem cell (McSC) system fails earlier than other adult
stem cell populations, which leads to hair greying in most humans and mice,. Current dogma …
stem cell populations, which leads to hair greying in most humans and mice,. Current dogma …
Epigenetic switch reshapes epithelial progenitor cell signatures and drives inflammatory pathogenesis in hidradenitis suppurativa
Hidradenitis suppurativa (HS) is a complex inflammatory skin disease with undefined
mechanistic underpinnings. Here, we investigated HS epithelial cells and demonstrated that …
mechanistic underpinnings. Here, we investigated HS epithelial cells and demonstrated that …
[HTML][HTML] Molecular and spatial landmarks of early mouse skin development
A wealth of specialized cell populations within the skin facilitates its hair-producing,
protective, sensory, and thermoregulatory functions. How the vast cell-type diversity and …
protective, sensory, and thermoregulatory functions. How the vast cell-type diversity and …
Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury
NA Veniaminova, YY Jia, AM Hartigan, TJ Huyge… - Cell reports, 2023 - cell.com
Sebaceous glands (SGs) release oils that protect our skin, but how these glands respond to
injury has not been previously examined. Here, we report that SGs are largely self-renewed …
injury has not been previously examined. Here, we report that SGs are largely self-renewed …
Injury prevents Ras mutant cell expansion in mosaic skin
Healthy skin is a mosaic of wild-type and mutant clones,. Although injury can cooperate with
mutated Ras family proteins to promote tumorigenesis,,,,,,,,–, the consequences in …
mutated Ras family proteins to promote tumorigenesis,,,,,,,,–, the consequences in …
[HTML][HTML] Single-cell and spatial transcriptomic analysis of human skin delineates intercellular communication and pathogenic cells
Epidermal homeostasis is governed by a balance between keratinocyte proliferation and
differentiation with contributions from cell–cell interactions, but conserved or divergent …
differentiation with contributions from cell–cell interactions, but conserved or divergent …
[HTML][HTML] A roadmap for a consensus human skin cell atlas and single-cell data standardization
Single-cell technologies have become essential to driving discovery in both basic and
translational investigative dermatology. Despite the multitude of available datasets, a central …
translational investigative dermatology. Despite the multitude of available datasets, a central …
Cell cycle controls long-range calcium signaling in the regenerating epidermis
Skin homeostasis is maintained by stem cells, which must communicate to balance their
regenerative behaviors. Yet, how adult stem cells signal across regenerative tissue remains …
regenerative behaviors. Yet, how adult stem cells signal across regenerative tissue remains …