Sepsis remains a major cause of morbidity and mortality worldwide, with increased burden
in low-and middle-resource settings. The role of the inflammatory response in the …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …

Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to infection. Myocardial dysfunction, often termed sepsis-induced cardiomyopathy …

Accumulating evidence suggests that the reactive oxygen and nitrogen species are
generated in cardiomyocytes and endothelial cells during myocardial ischemia/reperfusion …

Background & Aims Mitochondrial dysfunction, oxidative stress, inflammation, and metabolic
reprograming are crucial contributors to hepatic injury and subsequent liver fibrosis. Poly …

Dysregulation of nitric oxide (NO) and increased oxidative and nitrosative stress are
implicated in the pathogenesis of heart failure. Peroxynitrite is a reactive oxidant that is …

Heart failure is the major cause of hospitalization, morbidity and mortality worldwide.
Previous experimental and clinical studies have suggested that there is an increased …

Hyperglycemia-induced overproduction of superoxide by mitochondrial electron-transport
chain triggers several pathways of injury involved in the pathogenesis of diabetic …

Peroxynitrite is a reactive oxidant produced from nitric oxide and superoxide, which reacts
with proteins, lipids, and DNA, and promotes cytotoxic and proinflammatory responses …