GPCRs (G-protein [guanine nucleotide-binding protein]–coupled receptors) play a central
physiological role in the regulation of cardiac function in both health and disease and thus …

Cardiac hypertrophy is an adaptive and compensatory mechanism preserving cardiac
output during detrimental stimuli. Nevertheless, long-term stimuli incite chronic hypertrophy …

Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …

Rationale: The developing heart requires both mechanical load and vascularization to reach
its proper size, yet the regulation of human heart growth by these processes is poorly …

Aims Sex differences in hypertrophic cardiomyopathy (HCM) remain unclear. We sought to
characterize sex differences in a large HCM referral centre population. Methods and results …

Adrenergic receptors (AR) are G-protein-coupled receptors (GPCRs) that have a crucial role
in cardiac physiology in health and disease. Alpha 1-ARs signal through Gα q, and signaling …

Cardiac myocytes are activated by hormonal and mechanical signals and respond in a
variety of ways, from altering contractile function to inducing cardio-protection and growth …

Dysregulation of circadian rhythms associates with cardiovascular disorders. It is known that
deletion of the core circadian gene Bmal1 in mice causes dilated cardiomyopathy. However …

Rationale: It is unknown whether every ventricular myocyte expresses all 5 of the cardiac
adrenergic receptors (ARs), β1, β2, β3, α1A, and α1B. The β1 and β2 are thought to be the …

Cardiac remodeling is typically associated with disease and can lead to heart failure. In
contrast, remodeling that occurs in the athlete's heart is considered an adaptive …