The role of DNA damage and repair in liver cancer

R Gillman, KL Floro, M Wankell, L Hebbard - Biochimica et Biophysica Acta …, 2021 - Elsevier
Hepatocellular carcinoma is rapidly becoming a major cause of global mortality due to the
ever-increasing prevalence of obesity. DNA damage is known to play an important role in …

[HTML][HTML] Hepatocellular carcinoma and the risk of occupational exposure

V Rapisarda, C Loreto, M Malaguarnera… - World journal of …, 2016 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the most common type of liver cancer. The main risk
factors for HCC are alcoholism, hepatitis B virus, hepatitis C virus, nonalcoholic …

Architecture of the human Ape1 interactome defines novel cancers signatures

D Ayyildiz, G Antoniali, C D'Ambrosio… - Scientific Reports, 2020 - nature.com
APE1 is essential in cancer cells due to its central role in the Base Excision Repair pathway
of DNA lesions and in the transcriptional regulation of genes involved in tumor progression …

Hepatocellular carcinoma and possible chemical and biological causes: a review

P Erkekoglu, D Oral, MW Chao… - Journal of …, 2017 - dl.begellhouse.com
The development of hepatocellular carcinoma (HCC) is a multistep process. In HCC,
progressive and morphologically distinct preneoplastic lesions/alterations associated with …

Contribution of DNA double-strand break repair gene XRCC3 genotypes to triple-negative breast cancer risk

CH Su, WS Chang, PS Hu, CL Hsiao… - Cancer Genomics & …, 2015 - cgp.iiarjournals.org
Aim: The DNA-repair gene X-ray repair cross-complementing group 3 (XRCC3) is important
in DNA double-strand break repair and plays a critical part in initiation of carcinogenesis …

The contribution of matrix metalloproteinase-1 genotypes to hepatocellular carcinoma susceptibility in Taiwan

YL Lai, CL Gong, CK Fu, TC Yueh… - Cancer Genomics & …, 2017 - cgp.iiarjournals.org
Background/Aim: Metalloproteinases (MMPs) are a family of proteases which have been
shown to be overexpressed in various types of cancers. However, the contribution of MMP1 …

Role of polymorphic XRCC6 (Ku70)/XRCC7 (DNA-PKcs) genes towards susceptibility and prognosis of lung cancer patients undergoing platinum based doublet …

A Singh, N Singh, D Behera, S Sharma - Molecular biology reports, 2018 - Springer
The DNA repair genes XRCC6 and XRCC7 formed an integral part of double strand break
repair (DSBR) pathway. The two genes are thought to play an important role in the repair of …

Amentoflavone enhances the therapeutic efficacy of sorafenib by inhibiting anti-apoptotic potential and potentiating apoptosis in hepatocellular carcinoma in vivo

JJ Tsai, FT Hsu, PJ Pan, CW Chen… - Anticancer research, 2018 - ar.iiarjournals.org
Background/Aim: In a previous study, we showed that amentoflavone promotes sorafenib-
induced apoptosis in hepatocellular carcinoma (HCC) cells in vitro. However, whether …

The contribution of matrix metalloproteinase-7 promoter genotypes to hepatocellular carcinoma susceptibility

T Yueh, H Tsao, W Chien, C Tsai, J Pei… - Anticancer …, 2022 - ar.iiarjournals.org
Abstract Background/Aim: Metalloproteinase-7 (MMP-7) has been previously found to be up-
regulated in hepatocellular carcinoma (HCC) specimens and cells, favoring epithelial …

Genetic variants of the DNA repair genes from Exome Aggregation Consortium (EXAC) database: significance in cancer

R Das, SK Ghosh - DNA repair, 2017 - Elsevier
DNA repair pathway is a primary defense system that eliminates wide varieties of DNA
damage. Any deficiencies in them are likely to cause the chromosomal instability that leads …