Suramin is 100 years old and is still being used to treat the first stage of acute human
sleeping sickness, caused by Trypanosoma brucei rhodesiense. Suramin is a …

Electron microscopy may be useful in chemotherapy studies at distinct levels, such as the
identification of subcellular targets in the parasites and the elucidation of the ultimate drug …

The surface proteins of parasitic protozoa mediate functions essential to survival within a
host, including nutrient accumulation, environmental sensing and immune evasion. Several …

Background The protozoan Trypanosoma cruzi is the causative agent of Chagas disease.
There are no vaccines or effective treatment, especially in the chronic phase when most …

Although suramin (Sur) is suggested as a potential drug candidate in the management of
Chagas disease, this issue has not been objectively tested. In this study, we examined the …

Several β-carboline compounds were evaluated for in vitro trypanocidal activity against
Trypanosoma cruzi and their potential toxic effects was also assessed. β-Carboline …

The present paper aims to establish different treatments for neglected tropical disease by a
survey on drug conjugations and possible fixed-dose combinations (FDC) used to obtain …

The present work reports the isolation of acanthoic acid, a promising pimaradiene-type
diterpene with several important biological activities described in the literature, from the …

Polyanionic macromolecules are extremely abundant both in the extracellular environment
and inside the cell, where they are readily accessible to many proteins for interactions that …

Chagas disease, which is caused by the parasite Trypanosoma cruzi, affects approximately
7–8 million people in Latin America. The drugs available to treat this disease are ineffective …