Comet assay: an essential tool in toxicological research

M Glei, T Schneider, W Schlörmann - Archives of toxicology, 2016 - Springer
The comet assay is a versatile, reliable, cost-efficient, and fast technique for detecting DNA
damage and repair in any tissue. It is useable in almost any cell type and applicable to both …

[HTML][HTML] Cell-derived artificial nanovesicle as a drug delivery system for malignant melanoma treatment

YY Lin, CY Chen, DL Ma, CH Leung, CY Chang… - Biomedicine & …, 2022 - Elsevier
Extracellular vehicles have a natural targeting ability and immune tolerance of being usually
applied in drug delivery systems; however, the purification of EVs is complicated and the …

Photosensitized methyl paraben induces apoptosis via caspase dependent pathway under ambient UVB exposure in human skin cells

D Dubey, D Chopra, J Singh, AK Srivastav… - Food and chemical …, 2017 - Elsevier
Methyl paraben (MP), is a widely used preservative in pharmaceutical, food and cosmetic
products. Its molecular mechanism under ambient ultraviolet radiation is not well …

[HTML][HTML] UVB damage onset and progression 24 h post exposure in human-derived skin cells

C Khalil, W Shebaby - Toxicology reports, 2017 - Elsevier
The focus of this research was on UVB radiation (280–320 nm) responsible for cellular
changes in skin of acute and chronically exposed individuals. This study investigated the …

Photoexcited triclosan induced DNA damage and oxidative stress via p38 MAP kinase signaling involving type I radicals under sunlight/UVB exposure

D Dubey, AK Srivastav, J Singh, D Chopra… - Ecotoxicology and …, 2019 - Elsevier
Triclosan (TCS) is an antimicrobial preservative used in personal care products. Here, we
have studied the phototoxicity, photogenotoxicity of TCS and its molecular mechanism …

[HTML][HTML] The protection role of human growth hormone on skin cells following ultraviolet B exposure

B Taghizadeh, R Moradi, F Mirzavi, M Barati… - … of Photochemistry and …, 2024 - Elsevier
Abstract Background Ultraviolet-B (UVB) radiation is the leading environmental cause of
skin damage and photoaging. The epidermis and dermis layers of the skin mainly absorb …

Cellular and molecular responses to ethyl-parathion in undifferentiated SH-SY5Y cells provide neurotoxicity pathway indicators for organophosphorus impacts

SK Amar, KB Donohue, KA Gust - Toxicological Sciences, 2023 - academic.oup.com
High-fidelity nonanimal screening methods are needed that can rapidly and accurately
characterize organophosphorus compound (OP)-induced neurotoxicity. Herein, the efficacy …

Oxidative stress–mediated photoactivation of carbazole inhibits human skin cell physiology

AK Srivastav, D Dubey, D Chopra… - Journal of Cellular …, 2020 - Wiley Online Library
Prolonged exposure of the earth's surface to the sun's ultraviolet radiation may result in
various skin diseases and cataract. Carbazole (CBZ), as a polycyclic‐aromatic hydrocarbon …

Oxidovanadium (IV) complex disrupts mitochondrial membrane potential and induces apoptosis in pancreatic cancer cells

S Kowalski, A Tesmar, A Sikorski… - Anti-Cancer Agents …, 2021 - benthamdirect.com
Background: At the present time, there is a growing interest in metal-based anticancer
agents. Metal complexes exhibit many valuable clinical properties, however, due to toxicity …

[HTML][HTML] Oridonin enhances the anti-tumor activity of gemcitabine towards pancreatic cancer by stimulating Bax-and Smac-dependent apoptosis

DL Liu, HQ Bu, WL Wang, H Luo… - Translational Cancer …, 2020 - ncbi.nlm.nih.gov
Background Oridonin has been shown to exhibit potent anti-tumor activity, but the exact
mechanisms underlying this activity remains unclear. Here, we investigated whether …