[HTML][HTML] Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism

Z Cui, X Zhao, FK Amevor, X Du, Y Wang, D Li… - Frontiers in …, 2022 - frontiersin.org
Quercetin, a naturally non-toxic flavonoid within the safe dose range with antioxidant, anti-
apoptotic and anti-inflammatory properties, plays an important role in the treatment of aging …

A perspective on potential antibody-dependent enhancement of SARS-CoV-2

AM Arvin, K Fink, MA Schmid, A Cathcart, R Spreafico… - Nature, 2020 - nature.com
Antibody-dependent enhancement (ADE) of disease is a general concern for the
development of vaccines and antibody therapies because the mechanisms that underlie …

Rapid, ultrasensitive, and quantitative detection of SARS-CoV-2 using antisense oligonucleotides directed electrochemical biosensor chip

M Alafeef, K Dighe, P Moitra, D Pan - ACS nano, 2020 - ACS Publications
A large-scale diagnosis of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-
2) is essential to downregulate its spread within as well as across communities and mitigate …

Dengue

A Wilder-Smith, EE Ooi, O Horstick, B Wills - The Lancet, 2019 - thelancet.com
Mortality from severe dengue is low, but the economic and resource burden on health
services remains substantial in endemic settings. Unfortunately, progress towards …

A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice

R De Alwis, ES Gan, S Chen, YS Leong, HC Tan… - Molecular Therapy, 2021 - cell.com
A self-transcribing and replicating RNA (STARR)-based vaccine (LUNAR-COV19) has been
developed to prevent SARS-CoV-2 infection. The vaccine encodes an alphavirus-based …

Adaptive immune responses to primary and secondary dengue virus infections

AL St. John, APS Rathore - Nature Reviews Immunology, 2019 - nature.com
Dengue is the leading mosquito-borne viral illness infecting humans. Owing to the
circulation of multiple serotypes, global expansion of the disease and recent gains in …

Biochemistry and molecular biology of flaviviruses

NJ Barrows, RK Campos, KC Liao, KR Prasanth… - Chemical …, 2018 - ACS Publications
Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile,
yellow fever, and Zika viruses, are critically important human pathogens that sicken a …

Challenges and emergent solutions for LC‐MS/MS based untargeted metabolomics in diseases

L Cui, H Lu, YH Lee - Mass spectrometry reviews, 2018 - Wiley Online Library
In the past decade, advances in liquid chromatography‐mass spectrometry (LC‐MS) have
revolutionized untargeted metabolomics analyses. By mining metabolomes more deeply …

Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development

R De Alwis, S Chen, ES Gan, EE Ooi - EBioMedicine, 2020 - thelancet.com
The pandemic spread of a novel coronavirus–SARS coronavirus-2 (SARS-CoV-2) as a
cause of acute respiratory illness, named Covid-19, is placing the healthcare systems of …

The bright and the dark side of human antibody responses to flaviviruses: lessons for vaccine design

FA Rey, K Stiasny, MC Vaney, M Dellarole… - EMBO reports, 2018 - embopress.org
Zika and dengue viruses belong to the Flavivirus genus, a close group of antigenically
related viruses that cause significant arthropod‐transmitted diseases throughout the globe …