Animal models for SARS‐CoV‐2 research: a comprehensive literature review

K Pandey, A Acharya, M Mohan, CL Ng… - Transboundary and …, 2021 - Wiley Online Library
Emerging and re‐emerging viral diseases can create devastating effects on human lives
and may also lead to economic crises. The ongoing COVID‐19 pandemic due to the novel …

Reducing influenza virus transmission: the potential value of antiviral treatment

FG Hayden, J Asher, BJ Cowling… - Clinical Infectious …, 2022 - academic.oup.com
Prompt antiviral treatment has the potential to reduce influenza virus transmission to close
contacts, but rigorous data on the magnitude of treatment effects on transmission are limited …

Coinfection with SARS-CoV-2 and Influenza A Virus Increases Disease Severity and Impairs Neutralizing Antibody and CD4+ T Cell Responses

EH Kim, TQ Nguyen, MAB Casel, R Rollon… - Journal of …, 2022 - Am Soc Microbiol
Given the current coronavirus disease 2019 (COVID-19) pandemic, coinfection of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A virus (IAV) is a …

Animal models for influenza research: strengths and weaknesses

TQ Nguyen, R Rollon, YK Choi - Viruses, 2021 - mdpi.com
Influenza remains one of the most significant public health threats due to its ability to cause
high morbidity and mortality worldwide. Although understanding of influenza viruses has …

Influenza antivirals and animal models

CJ Caceres, B Seibert, F Cargnin Faccin… - FEBS open …, 2022 - Wiley Online Library
Influenza A and B viruses are among the most prominent human respiratory pathogens.
About 3–5 million severe cases of influenza are associated with 300 000–650 000 deaths …

Influenza polymerase inhibitor resistance: Assessment of the current state of the art-A report of the isirv Antiviral group

MG Ison, FG Hayden, AJ Hay, LV Gubareva… - Antiviral research, 2021 - Elsevier
It is more than 20 years since the neuraminidase inhibitors, oseltamivir and zanamivir were
approved for the treatment and prevention of influenza. Guidelines for global surveillance …

Block the Spread: Barriers to Transmission of Influenza Viruses

V Le Sage, AC Lowen… - Annual Review of …, 2023 - annualreviews.org
Respiratory viruses, such as influenza viruses, cause significant morbidity and mortality
worldwide through seasonal epidemics and sporadic pandemics. Influenza viruses transmit …

Effect of baloxavir and oseltamivir in combination on infection with influenza viruses with PA/I38T or PA/E23K substitutions in the ferret model

P Koszalka, A George, V Dhanasekaran, AC Hurt… - Mbio, 2022 - Am Soc Microbiol
Amino acid substitutions I38T and E23K in the influenza polymerase acidic (PA) protein lead
to reduced susceptibility to the influenza antiviral drug baloxavir. The in vivo effectiveness of …

Robustness of the ferret model for influenza risk assessment studies: a cross-laboratory exercise

JA Belser, EHY Lau, W Barclay, IG Barr, H Chen… - Mbio, 2022 - Am Soc Microbiol
Past pandemic influenza viruses with sustained human-to-human transmissibility have
emerged from animal influenza viruses. Employment of experimental models to assess the …

Exploring associations between viral titer measurements and disease outcomes in ferrets inoculated with 125 contemporary influenza A viruses

TJ Kieran, X Sun, TR Maines… - Journal of …, 2024 - Am Soc Microbiol
As use of the ferret model to study influenza A virus (IAV) pathogenicity increases, periodic
assessment of data generated in this model is warranted, to identify features associated with …