A comprehensive review of human trophoblast fusion models: recent developments and challenges

X Li, ZH Li, YX Wang, TH Liu - Cell Death Discovery, 2023 - nature.com
As an essential component of the maternal-fetal interface, the placental syncytiotrophoblast
layer contributes to a successful pregnancy by secreting hormones necessary for …

Spontaneous preterm birth: Involvement of multiple feto-maternal tissues and organ systems, differing mechanisms, and pathways

MS Vidal Jr, RCV Lintao, MEL Severino… - Frontiers in …, 2022 - frontiersin.org
Survivors of preterm birth struggle with multitudes of disabilities due to improper in utero
programming of various tissues and organ systems contributing to adult-onset diseases at a …

Amplification of microbial DNA from bacterial extracellular vesicles from human placenta

R Menon, K Khanipov, E Radnaa, E Ganguly… - Frontiers in …, 2023 - frontiersin.org
Introduction The placenta is essential for fetal growth and survival and maintaining a
successful pregnancy. The sterility of the placenta has been challenged recently; however …

Fetal inflammatory response at the fetomaternal interface: A requirement for labor at term and preterm

R Menon - Immunological reviews, 2022 - Wiley Online Library
Human parturition at term and preterm is an inflammatory process synchronously executed
by both fetomaternal tissues to transition them from a quiescent state t an active state of …

Role of Endometrial Extracellular Vesicles in Mediating Cell-to-Cell Communication in the Uterus: A Review

JR Beal, Q Ma, IC Bagchi, MK Bagchi - Cells, 2023 - mdpi.com
There are several critical events that occur in the uterus during early pregnancy which are
necessary for the establishment and maintenance of pregnancy. These events include …

Exosomes from Ureaplasma parvum-infected ectocervical epithelial cells promote feto-maternal interface inflammation but are insufficient to cause preterm delivery

OAG Tantengco, LS Richardson, E Radnaa… - Frontiers in cell and …, 2022 - frontiersin.org
This study determined if exosomes from ectocervical epithelial (ECTO) cells infected with
Ureaplasma parvum (U. parvum) can carry bacterial antigens and cause inflammation at the …

Review on new approach methods to gain insight into the feto-maternal interface physiology

R Menon, LJ Muglia, LH Levin - Frontiers in Medicine, 2023 - frontiersin.org
Non-human animals represent a large and important feature in the history of biomedical
research. The validity of their use, in terms of reproducible outcomes and translational …

Silencing P38 MAPK reduces cellular senescence in human fetal chorion trophoblast cells

B Goldman, E Radnaa, T Kechichian… - American Journal of …, 2023 - Wiley Online Library
Problem Amniochorion senescence generates mechanistic signals to initiate parturition.
Activation of p38 mitogen‐activated kinase (MAPK) in fetal amnion cells is a key mediator of …

In utero priming of fetal immune activation: Myths and mechanisms

MS Vidal Jr, R Menon - Journal of reproductive immunology, 2023 - Elsevier
Mechanisms of fetal immune system development in utero remain incompletely elucidated.
Protective immunity, the arm of reproductive immunology concerned with the progressive …

Association between maternal periodontitis and development of systematic diseases in offspring

A Starzyńska, P Wychowański, M Nowak… - International Journal of …, 2022 - mdpi.com
Periodontal disease (PD) is one of the most common oral conditions affecting both youths
and adults. There are some research works suggesting a high incidence of PD in pregnant …