Mycotoxin contamination continues to be a food safety concern globally, with the most toxic
being aflatoxins. On-farm aflatoxins, during food transit or storage, directly or indirectly result …

Traditional molecular techniques have been used in research in discovering the genes and
enzymes that are involved in aflatoxin formation and genetic regulation. We cloned most, if …

Microbial natural products are an invaluable source of evolved bioactive small molecules
and pharmaceutical agents. Next-generation and metagenomic sequencing indicates …

Fungal aromatic polyketides constitute a large family of bioactive natural products and are
synthesized by the non-reducing group of iterative polyketide synthases (PKSs). Their …

Species of the Fusarium fujikuroi species complex (FFC) cause a wide spectrum of often
devastating diseases on diverse agricultural crops, including coffee, fig, mango, maize, rice …

Fusarium fujikuroi produces a variety of secondary metabolites, of which polyketides form
the most diverse group. Among these are the highly pigmented naphthoquinones, which …

Cereals and cereal-based products are primary sources of nutrition across the world.
However, contamination of these foods with aflatoxins (AFs), secondary metabolites …

Genome sequencing has revealed that fungi have the ability to synthesize many more
natural products (NPs) than are currently known, but methods for obtaining suitable …

PksA, which initiates biosynthesis of the environmental carcinogen aflatoxin B1, is one of the
multidomain iterative polyketide synthases (IPKSs), a large, poorly understood family of …

Manipulation of the fungal epigenome is hypothesized to be an effective method for
accessing natural products from silent biosynthetic pathways. A library of epigenetic …