The continuing increase in the prevalence of diabetes mellitus in the general population is
predicted to result in a higher incidence of cardiovascular disease. Although the …

Alkaline phosphatase (ALP) is an evolutionary conserved enzyme and widely used
biomarker in clinical practice. Tissue-nonspecific alkaline phosphatase (TNALP) is one of …

Vascular and soft tissue calcification contributes to cardiovascular morbidity and mortality in
both the general population and CKD. Because calcium and phosphate serum …

Bone never forms without vascular interactions. This simple statement of fact does not
adequately reflect the physiological and pharmacological implications of the relationship …

The age-related vasculature alteration is the prominent risk factor for vascular diseases
(VD), namely, atherosclerosis, abdominal aortic aneurysm, vascular calcification (VC) and …

Calcific aortic valve disease (CAVD) increasingly afflicts our aging population. One third of
our elderly have echocardiographic or radiological evidence of calcific aortic valve sclerosis …

Vascular calcification is an unfavorable event in the natural history of atherosclerosis that
predicts cardiovascular morbidity and mortality. However, increasing evidence suggests that …

Atherosclerosis is one of the leading causes of death and disability worldwide. It is a
complex disease characterized by lipid accumulation within the arterial wall, inflammation …

Context: Type 2 diabetes mellitus (T2D) is associated with an increased risk of fractures and
low bone formation. However, the mechanism for the low bone formation is not well …

Diabetes mellitus increasingly afflicts our aging and dysmetabolic population. Type 2
diabetes mellitus and the antecedent metabolic syndrome represent the vast majority of the …