Over the past decade, the landscape of molecular synthesis has gained major impetus by
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …

Bolstered by recent advances in bioinformatics, genetics, and enzyme engineering, the field
of chemoenzymatic synthesis has enjoyed a rapid increase in popularity and utility. This …

Biocatalytic oxidations are an emerging technology for selective C− H bond activation. While
promising for a range of selective oxidations, practical use of enzymes catalyzing aerobic …

Direct C–H bond functionalization catalyzed by non-precious transition metals is an
attractive strategy in synthetic chemistry. Compared with the precious metals rhodium …

Enantioselective C–H oxidation is a standing chemical challenge foreseen as a powerful
tool to transform readily available organic molecules into precious oxygenated building …

The direct functionalization of C–H bonds constitutes a powerful strategy to construct and
diversify organic molecules. However, controlling the chemo-and site-selectivity of this …

Spurred by advancements in microbial genetics and enzyme engineering, chemoenzymatic
strategies, which combine enzymatic and synthetic transformations, have increasingly made …

The biological potency of natural products has been exploited for decades. Their inherent
structural complexity and natural diversity might hold the key to efficiently address the urgent …

Engineered metalloenzymes represent promising catalysts for stereoselective C–H
functionalization reactions. Recently, P450 enzymes have been evolved to allow for new-to …

Moroidin is a bicyclic plant octapeptide with tryptophan side-chain cross-links, originally
isolated as a pain-causing agent from the Australian stinging tree Dendrocnide moroides …