Equol: a bacterial metabolite from the daidzein isoflavone and its presumed beneficial health effects

B Mayo, L Vázquez, AB Flórez - Nutrients, 2019 - mdpi.com
Epidemiological data suggest that regular intake of isoflavones from soy reduces the
incidence of estrogen-dependent and aging-associated disorders, such as menopause …

Diverse effects of phytoestrogens on the reproductive performance: cow as a model

I Wocławek-Potocka, C Mannelli… - International journal …, 2013 - Wiley Online Library
Phytoestrogens, polyphenolic compounds derived from plants, are more and more common
constituents of human and animal diets. In most of the cases, these chemicals are much less …

Soy isoflavone genistein-mediated downregulation of miR-155 contributes to the anticancer effects of genistein

C De la Parra, L Castillo-Pichardo… - Nutrition and …, 2016 - Taylor & Francis
We previously reported that dietary genistein inhibits mammary tumor growth and metastasis
of the highly metastatic MDA-MB-435 cancer cells in immunocompromised mice. The …

S-equol, a metabolite of dietary soy isoflavones, alleviates lipopolysaccharide-induced depressive-like behavior in mice by inhibiting neuroinflammation and …

C Lu, R Gao, Y Zhang, N Jiang, Y Chen, J Sun… - Food & Function, 2021 - pubs.rsc.org
Systemic injection with lipopolysaccharide can lead to depressive-like behavior in
experimental animals by inducing neuroinflammation and is considered to be a classic …

Targeting breast cancer stem cells using naturally occurring phytoestrogens

M Nguyen, C Osipo - International Journal of Molecular Sciences, 2022 - mdpi.com
Breast cancer therapies have made significant strides in improving survival for patients over
the past decades. However, recurrence and drug resistance continue to challenge long-term …

Chiral flavonoids as antitumor agents

C Pinto, H Cidade, M Pinto, ME Tiritan - Pharmaceuticals, 2021 - mdpi.com
Flavonoids are a group of natural products with a great structural diversity, widely distributed
in plant kingdom. They play an important role in plant growth, development and defense …

Enhanced MET translation and signaling sustains K-Ras–driven proliferation under anchorage-independent growth conditions

S Fujita-Sato, J Galeas, M Truitt, C Pitt, A Urisman… - Cancer research, 2015 - AACR
Oncogenic K-Ras mutation occurs frequently in several types of cancers, including
pancreatic and lung cancers. Tumors with K-Ras mutation are resistant to chemotherapeutic …

Soy isoflavone-specific biotransformation product S-equol in the colon: Physiological functions, transformation mechanisms, and metabolic regulatory pathways

X Wang, B Chen, X Fang, Q Zhong, Z Liao… - Critical Reviews in …, 2024 - Taylor & Francis
Epidemiological data suggest that regular intake of soy isoflavones may reduce the
incidence of estrogen-dependent and aging-associated disorders. Equol is a metabolite of …

Tailoring Potential Natural Compounds for the Treatment of Luminal Breast Cancer

FC da Silva, DC Brandão, EA Ferreira, RP Siqueira… - Pharmaceuticals, 2023 - mdpi.com
Breast cancer (BC) is the most diagnosed cancer worldwide, mainly affecting the epithelial
cells from the mammary glands. When it expresses the estrogen receptor (ER), the tumor is …

Soy and frequent dairy consumption with subsequent equol production reveals decreased gut health in a cohort of healthy Puerto Rican women

MY Lacourt-Ventura, B Vilanova-Cuevas… - International Journal of …, 2021 - mdpi.com
The US Hispanic female population has one of the highest breast cancer (BC) incidence
and mortality rates, while BC is the leading cause of cancer death in Puerto Rican women …