Comparative oncology: overcoming human cancer through companion animal studies
Comparative oncology is a field of study that has been recently adopted for studying cancer
and developing cancer therapies. Companion animals such as dogs can be used to …
and developing cancer therapies. Companion animals such as dogs can be used to …
Bifunctional chemical probes inducing protein–protein interactions
Inducing biomolecular interactions with synthetic molecules to impact biological function is a
concept of enormous appeal. Recent years have seen a resurgence of interest in designing …
concept of enormous appeal. Recent years have seen a resurgence of interest in designing …
Targeting BET bromodomain proteins in cancer: The example of lymphomas
Abstract The Bromo-and Extra-Terminal domain (BET) family proteins act as “readers” of
acetylated histones and they are important transcription regulators. BRD2, BRD3, BRD4 and …
acetylated histones and they are important transcription regulators. BRD2, BRD3, BRD4 and …
Antitumor activity of the dual BET and CBP/EP300 inhibitor NEO2734
Bromodomain and extra-terminal domain (BET) proteins, cyclic adenosine monophosphate
response element-binding protein (CBP), and the E1A-binding protein of p300 (EP300) are …
response element-binding protein (CBP), and the E1A-binding protein of p300 (EP300) are …
The genetic and molecular basis for canine models of human leukemia and lymphoma
AC Avery - Frontiers in oncology, 2020 - frontiersin.org
Emerging details of the gene expression and mutational features of canine lymphoma and
leukemia demonstrate areas of similarities and differences between disease subsets in the …
leukemia demonstrate areas of similarities and differences between disease subsets in the …
NF-kB activation in canine cancer
LJ Schlein, DH Thamm - Veterinary pathology, 2022 - journals.sagepub.com
Spontaneous tumors in dogs share several environmental, epidemiologic, biologic, clinical
and molecular features with a wide variety of human cancers, making this companion animal …
and molecular features with a wide variety of human cancers, making this companion animal …
Pqr309, a dual pi3k/mtor inhibitor, synergizes with gemcitabine by impairing the gsk-3β and stat3/hsp60 signaling pathways to treat nasopharyngeal carcinoma
J Cao, K Zeng, Q Chen, T Yang, F Lu, C Lin… - Cell Death & …, 2024 - nature.com
End-stage nasopharyngeal carcinoma (NPC) has unsatisfactory survival. The limited benefit
of chemotherapy and the scarcity of targeted drugs are major challenges in NPC. New …
of chemotherapy and the scarcity of targeted drugs are major challenges in NPC. New …
Is there a role for dual PI3K/mTOR inhibitors for patients affected with lymphoma?
The activation of the PI3K/AKT/mTOR pathway is a main driver of cell growth, proliferation,
survival, and chemoresistance of cancer cells, and, for this reason, represents an attractive …
survival, and chemoresistance of cancer cells, and, for this reason, represents an attractive …
Increased programmed death ligand (PD-L1) and cytotoxic T-lymphocyte antigen-4 (CTLA-4) expression is associated with metastasis and poor prognosis in …
Aberrant expression of immune check point molecules, programmed death ligand (PD-L1)
and cytotoxic T-lymphocyte antigen-4 (CTLA-4) has been reported in many human cancers …
and cytotoxic T-lymphocyte antigen-4 (CTLA-4) has been reported in many human cancers …
The K9 lymphoma assay allows a genetic subgrouping of canine lymphomas with improved risk classification
A Fanelli, L Licenziato, E Mazzone, S Divari… - Scientific Reports, 2024 - nature.com
We present here the K9 lymphoma assay, a novel 31-gene targeted next-generation
sequencing panel designed for genomic profiling of canine lymphoid neoplasms …
sequencing panel designed for genomic profiling of canine lymphoid neoplasms …