Cardiovascular disease is a leading cause of death, and translational research is needed to
understand better mechanisms whereby the left ventricle responds to injury. Mouse models …

Background: The impact of sex on phenotypic expression in hypertrophic cardiomyopathy
(HCM) has not been well characterized in genotyped cohorts. Methods: Retrospective cohort …

To advance research in hypertrophic cardiomyopathy (HCM), and guide researchers in
choosing the optimal model to answer their research questions, we performed a systematic …

The cardiovascular benefits of regular exercise are unequivocal, yet patients with type 2
diabetes respond poorly to exercise due to a reduced cardiac reserve. The contractile …

Background Previous studies have indicated that inefficient energy utilization may play a
pivotal role in hypertrophic cardiomyopathy (HCM). However, whether plasma free fatty acid …

Mechanistic complexity of contractile dysfunction in hypertrophic cardiomyopathy | Journal of
General Physiology | Rockefeller University Press Skip to Main Content Advertisement …

Objective: ABO blood type is associated with cardiovascular diseases. Several studies have
suggested sex-related differences in both hypertrophic cardiomyopathy (HCM) clinical …

The heart undergoes extensive morphological, metabolic, and energetic remodeling in
response to inherited, or familial, hypertrophic cardiomyopathies (FHC). Myocyte contractile …

BACKGROUND: The impact of sex on phenotypic expression in hypertrophic
cardiomyopathy (HCM) has not been well characterized in genotyped cohorts. METHODS …

Premenopausal women are protected against cardiovascular disease (CVD) compared to
age-matched men. The cellular and molecular mechanisms underlying the transition from …