Free radical-induced macromolecular damage has been studied extensively as a
mechanism of oxidative stress, but large-scale intervention trials with free radical …

Nuclear factor-κB (NF-κB) is a transcription factor that plays a crucial role in coordinating
innate and adaptive immunity, inflammation, and apoptotic cell death. NF-κB is activated by …

Based on mosaic theory, hypertension is a multifactorial disorder that develops because of
genetic, environmental, anatomical, adaptive neural, endocrine, humoral, and hemodynamic …

Alzheimer's disease (AD) is the most prevalent cause of dementia and is pathologically
characterized by the presence of parenchymal senile plaques composed of amyloid β (Aβ) …

Improved methods for studying intracellular reactive Fe (ii) are of significant interest for
studies of iron metabolism and disease-relevant changes in iron homeostasis. Here we …

Introduction. Paracetamol (acetaminophen) is one of the most common agents deliberately
ingested in self-poisoning episodes and a leading cause of acute liver failure in the western …

The mitochondria-targeted drug mitoquinone (MitoQ) has been used as an antioxidant that
may selectively block mitochondrial oxidative damage; however, it has been recently …

Coenzyme Q (Q) is a key component for bioenergetics and antioxidant protection in the cell.
During the last years, research on diseases linked to Q-deficiency has highlighted the …

Background Hydrogen sulfide (H2S), the third physiologically relevant gaseous molecule, is
recognized increasingly as an anti-inflammatory mediator in various inflammatory …

Reversible protein S-glutathiolation has emerged as an important mechanism of post-
translational modification. Under basal conditions several proteins remain adducted to …