This working group of the International Society of Hepatic Encephalopathy and Nitrogen
Metabolism (ISHEN) was commissioned to summarize and update current efforts in the …

Among the nine mammalian protein arginine methyltransferases (PRMTs), PRMT8 is
unusual because it has restricted expression in the nervous system and is the only …

Excitatory synapses of neurons are located on dendritic spines. Spine maturation is
essential for the stability of synapses and memory consolidation, and overproduction of the …

Abstract Protein phosphatase 1 (PP1) catalyzes more than half of all phosphoserine/
threonine dephosphorylation reactions in mammalian cells. In vivo PP1 does not exist as a …

Neuropeptide Y (NPY) is an endogenous neuropeptide that is abundantly expressed in the
central nervous system. NPY is involved in various neurological processes and …

Anxiety and depression are central nervous system illnesses that are among the most
prevalent medical concerns of the twenty-first century. Patients with this condition and their …

Aim The aim of the study was to investigate the factors that underpin neuropsychiatric
symptoms and how they might evolve over time in people with Mild Cognitive Impairment …

GABAergic dysfunction has been implicated in a variety of neurological and psychiatric
disorders, including anxiety disorders. Anxiety disorders are the most common type of …

Aberrant regulation and activity of synaptic proteins may cause synaptic pathology in the
prefrontal cortex (PFC) of mood disorder patients. Carboxy-terminal PDZ ligand of NOS1 …

Spinophilin is the most abundant protein phosphatase 1 targeting protein in the postsynaptic
density of dendritic spines. Spinophilin associates with myriad synaptic proteins to regulate …