After anaphase onset, animal cells build an actomyosin contractile ring that constricts the
plasma membrane to generate two daughter cells connected by a cytoplasmic bridge. The …

Recent evidence indicates that metastatic capacity is an inherent feature of breast tumours
and not a rare, late acquired event. This has led to new models of metastasis. The …

The biology and behavior of adults differ substantially from those of developing animals, and
cell-specific information is critical for deciphering the biology of multicellular animals. Thus …

The nematode C. elegans is attracted to nutritious bacteria and is repelled by pathogens
and toxins. Here we show that RNAi and toxin-mediated disruption of core cellular activities …

Cytokinesis is a temporally and spatially regulated process through which the cellular
constituents of the mother cell are partitioned into two daughter cells, permitting an increase …

The actin cytoskeleton is one of the major structural components of the cell. It often
undergoes rapid reorganization and plays crucial roles in a number of dynamic cellular …

Cofilin is essential for cell viability and for actin-based motility. Cofilin severs actin filaments,
which enhances the dynamics of filament assembly. We investigated the mechanism of …

Actin and microtubules are major cytoskeletal elements of most cells including neurons. In
order for a cell to move and change shape, its cytoskeleton must undergo rearrangements …

Actin depolymerizing factor (ADF)/cofilin enhances turnover of actin filaments by severing
and depolymerizing filaments. A number of proteins functionally interact with ADF/cofilin to …

Actin filaments form contractile and protrusive structures that play central roles in many
processes such as cell migration, morphogenesis, endocytosis, and cytokinesis. During …