The mineralocorticoid receptor (MR) and its ligand aldosterone are the principal modulators
of hormone-regulated renal sodium reabsorption. In addition to the kidney, there are several …

The primary adrenal cortical steroid hormones, aldosterone, and the glucocorticoids cortisol
and corticosterone, act through the structurally similar mineralocorticoid (MR) and …

Background—In obesity, the excessive synthesis of aldosterone contributes to the
development and progression of metabolic and cardiovascular dysfunctions. Obesity …

Hypertension (HTN) is present in more than 50% of patients with diabetes mellitus (DM) and
contributes significantly to both microvascular and macrovascular disease in DM (Fig. 1). 1 …

Obesity is an emerging pandemic driven by consumption of a diet rich in fat and highly
refined carbohydrates (a Western diet) and a sedentary lifestyle in both children and adults …

Epidemiological studies support the notion that arterial stiffness is an independent predictor
of adverse cardiovascular events contributing significantly to systolic hypertension, impaired …

Aldosterone is a steroid hormone synthesized in and secreted from the outer layer of the
adrenal cortex, the zona glomerulosa. Aldosterone is responsible for regulating sodium …

The mineralocorticoid receptor (MR) controls adipocyte function, but its role in the
conversion of white adipose tissue (WAT) into thermogenic fat has not been elucidated. We …

Type 2 diabetes mellitus (T2DM) is a risk factor that plays a major role in the onset of heart
failure (HF) both directly, by impairing cardiac function, and indirectly, through associated …

Aims An excessive production of aldosterone influences outcome in patients with heart
failure (HF) and in obese patients. Findings from laboratory studies suggest that chronic …