Telomerase is a ribonucleoprotein complex, the catalytic core of which includes the
telomerase reverse transcriptase (TERT) and the non-coding human telomerase RNA (hTR) …

Cellular senescence is an irreversible growth arrest that occurs as a result of different
damaging stimuli, including DNA damage, telomere shortening and dysfunction or …

With advances in genomic sequencing technology, the number of reported gene-disease
relationships has rapidly expanded. However, the evidence supporting these claims varies …

Small nucleolar RNAs (snoRNAs) are short non-protein-coding RNAs with a long-
recognized role in tuning ribosomal and spliceosomal function by guiding ribose methylation …

Recent progresses in the field of Induced Pluripotent Stem Cells (iPSCs) have opened up
many gateways for the research in therapeutics. iPSCs are the cells which are …

The field of stem-cell biology has been catapulted forward by the startling development of
reprogramming technology. The ability to restore pluripotency to somatic cells through the …

The underlying cause of aging remains one of the central mysteries of biology. Recent
studies in several different systems suggest that not only may the rate of aging be modified …

Worldwide increases in life expectancy have been paralleled by a greater prevalence of
chronic and age-associated disorders, particularly of the cardiovascular, neural and …

Mutations in the human telomerase reverse transcriptase (TERT) promoter are the most
frequent non-coding mutations in cancer, but their molecular mechanism in tumorigenesis …

The ability to generate induced pluripotent stem cells (iPSCs) from patients, and an
increasingly refined capacity to differentiate these iPSCs into disease-relevant cell types …