Fungal secondary metabolism: regulation, function and drug discovery

NP Keller - Nature Reviews Microbiology, 2019 - nature.com
One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …

The birth, evolution and death of metabolic gene clusters in fungi

A Rokas, JH Wisecaver, AL Lind - Nature Reviews Microbiology, 2018 - nature.com
Fungi contain a remarkable diversity of both primary and secondary metabolic pathways
involved in ecologically specialized or accessory functions. Genes in these pathways are …

Cblaster: a remote search tool for rapid identification and visualization of homologous gene clusters

CLM Gilchrist, TJ Booth, B van Wersch… - Bioinformatics …, 2021 - academic.oup.com
Motivation Genes involved in coordinated biological pathways, including metabolism, drug
resistance and virulence, are often collocalized as gene clusters. Identifying homologous …

A global coexpression network approach for connecting genes to specialized metabolic pathways in plants

JH Wisecaver, AT Borowsky, V Tzin, G Jander… - The Plant …, 2017 - academic.oup.com
Plants produce diverse specialized metabolites (SMs), but the genes responsible for their
production and regulation remain largely unknown, hindering efforts to tap plant …

Fungal evolutionary genomics provides insight into the mechanisms of adaptive divergence in eukaryotes

P Gladieux, J Ropars, H Badouin, A Branca… - Molecular …, 2014 - Wiley Online Library
Fungi are ideal model organisms for dissecting the genomic bases of adaptive divergence in
eukaryotes. They have simple morphologies and small genomes, occupy contrasting, well …

Strategies for mining fungal natural products

P Wiemann, NP Keller - Journal of Industrial Microbiology and …, 2014 - academic.oup.com
Fungi are well known for their ability to produce a multitude of natural products. On the one
hand their potential to provide beneficial antibiotics and immunosuppressants has been …

Mycotoxin producers in the Aspergillus genus: An update

J Varga, N Baranyi, M Chandrasekaran… - Acta Biologica …, 2015 - 160.114.156.156
Mycotoxins are secondary metabolites of fungi. Species assigned to the Aspergillus genus
produce a wide range of mycotoxins which can contaminate several agricultural products …

Plant metabolic gene clusters: evolution, organization, and their applications in synthetic biology

R Bharadwaj, SR Kumar, A Sharma… - Frontiers in Plant …, 2021 - frontiersin.org
Plants are a remarkable source of high-value specialized metabolites having significant
physiological and ecological functions. Genes responsible for synthesizing specialized …

Elucidation of cladofulvin biosynthesis reveals a cytochrome P450 monooxygenase required for anthraquinone dimerization

S Griffiths, CH Mesarich… - Proceedings of the …, 2016 - National Acad Sciences
Anthraquinones are a large family of secondary metabolites (SMs) that are extensively
studied for their diverse biological activities. These activities are determined by functional …

Cladosporium fulvum Effectors: Weapons in the Arms Race with Tomato

PJGM de Wit - Annual Review of Phytopathology, 2016 - annualreviews.org
In this review, I recount my personal history. My drive to study host-pathogen interactions
was to find alternatives for agrochemicals, which was triggered after reading the book “Silent …