Toward widespread use of virtual trials in medical imaging innovation and regulatory science

E Abadi, B Barufaldi, M Lago, A Badal… - Medical …, 2024 - Wiley Online Library
The rapid advancement in the field of medical imaging presents a challenge in keeping up
to date with the necessary objective evaluations and optimizations for safe and effective use …

Emphysema quantifications with CT scan: assessing the effects of acquisition protocols and imaging parameters using virtual imaging trials

E Abadi, G Jadick, DA Lynch, WP Segars, E Samei - Chest, 2023 - Elsevier
Background CT scan has notable potential to quantify the severity and progression of
emphysema in patients. Such quantification should ideally reflect the true attributes and …

A systematic assessment and optimization of photon‐counting CT for lung density quantifications

S Sotoudeh‐Paima, WP Segars, D Ghosh… - Medical …, 2024 - Wiley Online Library
Background Photon‐counting computed tomography (PCCT) has recently emerged into
clinical use; however, its optimum imaging protocols and added benefits remains unknown …

Deep silicon photon-counting CT: A first simulation-based study for assessing perceptual benefits across diverse anatomies

S Sharma, D Pal, E Abadi, P Segars, J Hsieh… - European Journal of …, 2024 - Elsevier
Objectives To assess perceptual benefits provided by the improved spatial resolution and
noise performance of deep silicon photon-counting CT (Si-PCCT) over conventional energy …

A systematic assessment of photon-counting CT for bone mineral density and microarchitecture quantifications

C McCabe, TJ Sauer, M Zarei… - … 2023: Physics of …, 2023 - spiedigitallibrary.org
Photon-counting CT (PCCT) is an emerging imaging technology with potential
improvements in quantification and rendition of micro-structures due to its smaller detector …

Photon-counting computed tomography versus energy-integrating computed tomography for detection of small liver lesions: comparison using a virtual framework …

N Felice, B Wildman-Tobriner… - Journal of Medical …, 2024 - spiedigitallibrary.org
Purpose Photon-counting computed tomography (PCCT) has the potential to provide
superior image quality to energy-integrating CT (EICT). We objectively compare PCCT to …

Development and application of a virtual imaging trial framework for airway quantifications via CT

FC Ho, S Sotoudeh-Paima, WP Segars… - … 2023: Physics of …, 2023 - spiedigitallibrary.org
Chronic obstructive pulmonary disease (COPD) is one of the top three causes of death
worldwide, characterized by emphysema and bronchitis. Airway measurements reflect the …

Quantitative accuracy of lung function measurement using parametric response mapping: A virtual imaging study

A Kavuri, FC Ho, M Ghojogh-Nejad… - Medical Imaging …, 2024 - spiedigitallibrary.org
Parametric response mapping (PRM) is a voxel-based quantitative CT imaging biomarker
that measures the severity of chronic obstructive pulmonary disease (COPD) by analyzing …

Implementation and Applications of Virtual Imaging Trials in Computed Tomography

N Felice - 2023 - search.proquest.com
Virtual imaging is a powerful tool that offers an alternative to clinical trials by simulating
medical image acquisitions. Virtual trials allow for the generation of large data sets without …