P-bodies: composition, properties, and functions
Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein (RNP) granules primarily
composed of translationally repressed mRNAs and proteins related to mRNA decay …
composed of translationally repressed mRNAs and proteins related to mRNA decay …
P-bodies: cytosolic droplets for coordinated mRNA storage
N Standart, D Weil - Trends in Genetics, 2018 - cell.com
P-bodies (PBs) are cytosolic RNP granules that are conserved among eukaryotic organisms.
In the past few years, major progress has been made in understanding the biochemical and …
In the past few years, major progress has been made in understanding the biochemical and …
GC content shapes mRNA storage and decay in human cells
mRNA translation and decay appear often intimately linked although the rules of this
interplay are poorly understood. In this study, we combined our recent P-body transcriptome …
interplay are poorly understood. In this study, we combined our recent P-body transcriptome …
Increased G3BP2-Tau interaction in tauopathies is a natural defense against Tau aggregation
C Wang, M Terrigno, J Li, T Distler, NJ Pandya… - Neuron, 2023 - cell.com
Many RNA-binding proteins (RBPs), particularly those associated with RNA granules,
promote pathological protein aggregation in neurodegenerative diseases. Here, we …
promote pathological protein aggregation in neurodegenerative diseases. Here, we …
The Signaling Pathways Project, an integrated 'omics knowledgebase for mammalian cellular signaling pathways
SA Ochsner, D Abraham, K Martin, W Ding, A McOwiti… - Scientific data, 2019 - nature.com
Mining of integrated public transcriptomic and ChIP-Seq (cistromic) datasets can illuminate
functions of mammalian cellular signaling pathways not yet explored in the research …
functions of mammalian cellular signaling pathways not yet explored in the research …
SUMO: glue or solvent for phase-separated ribonucleoprotein complexes and molecular condensates?
J Keiten-Schmitz, L Röder, E Hornstein… - Frontiers in molecular …, 2021 - frontiersin.org
Spatial organization of cellular processes in membranous or membrane-less organelles
(MLOs, alias molecular condensates) is a key concept for compartmentalizing biochemical …
(MLOs, alias molecular condensates) is a key concept for compartmentalizing biochemical …
Novel FMRP interaction networks linked to cellular stress
MS Taha, F Haghighi, A Stefanski… - The FEBS …, 2021 - Wiley Online Library
Silencing of the fragile X mental retardation 1 (FMR1) gene and consequently lack of
synthesis of FMR protein (FMRP) are associated with fragile X syndrome, which is one of the …
synthesis of FMR protein (FMRP) are associated with fragile X syndrome, which is one of the …
Succinyl-CoA ligase ADP-forming subunit beta promotes stress granule assembly to regulate redox and drive cancer metastasis
Although recent studies demonstrate active mitochondrial metabolism in cancers, the
precise mechanisms through which mitochondrial factors contribute to cancer metastasis …
precise mechanisms through which mitochondrial factors contribute to cancer metastasis …
LSM12 and ME31B/DDX6 define distinct modes of posttranscriptional regulation by ATAXIN-2 protein complex in Drosophila circadian pacemaker neurons
Summary ATAXIN-2 (ATX2) has been implicated in human neurodegenerative diseases, yet
it remains elusive how ATX2 assembles specific protein complexes to execute its …
it remains elusive how ATX2 assembles specific protein complexes to execute its …
A novel human-specific splice isoform alters the critical C-terminus of Survival Motor Neuron protein
Spinal muscular atrophy (SMA), a leading genetic disease of children and infants, is caused
by mutations or deletions of Survival Motor Neuron 1 (SMN1) gene. SMN2, a nearly identical …
by mutations or deletions of Survival Motor Neuron 1 (SMN1) gene. SMN2, a nearly identical …