Antiphospholipid syndrome: advances in diagnosis, pathogenesis, and management

JS Knight, DW Branch, TL Ortel - bmj, 2023 - bmj.com
Antiphospholipid syndrome (APS) is a thrombo-inflammatory disease propelled by
circulating autoantibodies that recognize cell surface phospholipids and phospholipid …

Pathogenesis, diagnosis and management of obstetric antiphospholipid syndrome: a comprehensive review

J Alijotas-Reig, E Esteve-Valverde… - Journal of clinical …, 2022 - mdpi.com
Antiphospholipid syndrome is an autoimmune disorder characterized by vascular
thrombosis and/or pregnancy morbidity associated with persistent antiphospholipid antibody …

Recurrent miscarriage: evidence to accelerate action

A Coomarasamy, RK Dhillon-Smith, A Papadopoulou… - The Lancet, 2021 - thelancet.com
Women who have had repeated miscarriages often have uncertainties about the cause, the
likelihood of recurrence, the investigations they need, and the treatments that might help …

Heparin for women with recurrent miscarriage and inherited thrombophilia (ALIFE2): an international open-label, randomised controlled trial

S Quenby, K Booth, L Hiller, A Coomarasamy… - The Lancet, 2023 - thelancet.com
Background Anticoagulant therapy might reduce the number of miscarriages and adverse
pregnancy outcomes in women with recurrent pregnancy loss and inherited thrombophilia …

Chronic inflammatory placental disorders associated with recurrent adverse pregnancy outcome

EF Cornish, T McDonnell, DJ Williams - Frontiers in Immunology, 2022 - frontiersin.org
Chronic inflammatory placental disorders are a group of rare but devastating gestational
syndromes associated with adverse pregnancy outcome. This review focuses on three …

Immunological risk factors in recurrent pregnancy loss: guidelines versus current state of the art

K Vomstein, K Feil, L Strobel, A Aulitzky… - Journal of clinical …, 2021 - mdpi.com
Around 1–5% of all couples experience recurrent pregnancy loss (RPL). Established risk
factors include anatomical, genetic, endocrine, and hemostatic alterations. With around 50 …

Thrombophilia, thrombosis and thromboprophylaxis in pregnancy: for what and in whom?

S Middeldorp, C Naue, C Köhler - Hämostaseologie, 2022 - thieme-connect.com
Compared with nonpregnant women, pregnancy carries a four-to fivefold higher risk of
venous thromboembolism (VTE). Despite increasing use of heparin prophylaxis in identified …

Prevalence and differences in the co-administration of drugs known to interact: an analysis of three distinct and large populations

J Sánchez-Valle, RB Correia, M Camacho-Artacho… - BMC medicine, 2024 - Springer
Background The co-administration of drugs known to interact greatly impacts morbidity,
mortality, and health economics. This study aims to examine the drug–drug interaction (DDI) …

Antiphospholipid syndrome management: a 2023 update and practical algorithm-based approach

A Ambati, JS Knight, Y Zuo - Current opinion in rheumatology, 2023 - journals.lww.com
Although the knowledge of APS pathogenesis has grown in recent years, the management
principles and strategies are largely unchanged. There is an unmet need for evaluating …

Progesterone for women with threatened miscarriage (STOP trial): a placebo-controlled randomized clinical trial

LA McLindon, G James, MM Beckmann… - Human …, 2023 - academic.oup.com
STUDY QUESTION In women with threatened miscarriage, does progesterone
supplementation until the completion of the first trimester of pregnancy increase the …