Aptamers comprise a range of molecular recognition scaffolds that can be engineered to
bind to a legion of different proteins and other targets with excellent specificity and affinity …

Aptamers are single-stranded DNA or RNA sequences that bind target molecules with high
specificity and affinity. Aptamers exhibit several notable advantages over protein-based …

The tight electrostatic binding of the chemokine platelet factor 4 (PF4) to polyanions induces
heparin-induced thrombocytopenia, a prothrombotic adverse drug reaction caused by …

Nucleic acid aptamers, or simply aptamers, are oligonucleotides that bind specific ligands
that vary from small molecules to proteins. An aptamer for a specific ligand is routinely …

The selection of nucleic acid aptamers is an increasingly important approach to generate
specific ligands binding to virtually any molecule of choice. However, selection-inherent …

Aptamers, simply described as chemical antibodies, are synthetic oligonucleotide ligands or
peptides that can be isolated in vitro against diverse targets including toxins, bacterial and …

Ingestion or inhalation of botulinum neurotoxin (BoNT) results in botulism, a severe and
frequently fatal disease. Current treatments rely on antitoxins, which, while effective, cannot …

Emerging applications of aptamers for anticoagulation and he... : Current Opinion in
Hematology Emerging applications of aptamers for anticoagulation and hemostasis : Current …

As a novel class of therapeutics, aptamers, or nucleic acid ligands, have garnered clinical
interest because of the ease of isolating a highly specific aptamer against a wide range of …

Background: Human‐activated protein C (APC) is a serine protease with anticoagulant, anti‐
inflammatory and cytoprotective functions. This feature renders APC to be a promising …